Classic and new diagnostic approaches to childhood tuberculosis.
Classic and new diagnostic approaches to childhood tuberculosis.
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DOI：
10.1155/2012/818219
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发表时间：
2012
影响因子：
2.2
通讯作者：
Prado Montes de Oca E
中科院分区：
文献类型：
--
作者：
López Ávalos GG;Prado Montes de Oca E
儿童结核病不同于成人的临床形式，甚至由于其鉴别体征而被认为是一种不同的疾病。然而，预防、诊断和治疗工作一直偏向于成人临床护理。需要新的诊断方法的灵敏度和特异性，如GeneXpert、电子鼻（E-nose）、红外光谱、磁性诱导的加速分枝杆菌生长和儿童人群中的流动侧向装置。对儿童结核病感染进行充分和及时的评估可以减轻流行病学负担，因为诊断不足的儿科患者可以发展为活跃状态，并有可能传播病原体结核分枝杆菌，特别是增加这一全球公共卫生问题。
Tuberculosis in childhood differs from the adult clinical form and even has been suggested that it is a different disease due to its differential signs. However, prevention, diagnostics, and therapeutic efforts have been biased toward adult clinical care. Sensibility and specificity of new diagnostic approaches as GeneXpert, electronic nose (E-nose), infrared spectroscopy, accelerated mycobacterial growth induced by magnetism, and flow lateral devices in children populations are needed. Adequate and timely assessment of tuberculosis infection in childhood could diminish epidemiological burden because underdiagnosed pediatric patients can evolve to an active state and have the potential to disseminate the etiological agent Mycobacterium tuberculosis, notably increasing this worldwide public health problem.