Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression
Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression
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DOI：
10.1093/jnci/91.6.512
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发表时间：
1999-03-17
影响因子：
10.3
通讯作者：
Clinton, SK
中科院分区：
文献类型：
--
作者：
Mukherjee, P;Sotnikov, AV;Clinton, SK
Background: A sedentary lifestyle coupled with excessive energy intake is speculated to be a factor associated with increased incidence of prostate cancer. We have investigated the effects of energy intake on prostate tumor growth in experimental animals, Methods: Two transplantable prostate tumor models, i.e., the androgen-dependent Dunning R3327-H adenocarcinoma in rats and the androgen-sensitive LNCaP human carcinoma in severe combined immunodeficient mice, were studied. R3327-H tumor growth and relevant tumor biomarkers (proliferation index, apoptosis [programmed cell death], microvessel density, and vascular endothelial growth factor [VEGF] expression) were compared in ad libitum fed control rats, ad libitum fed castrated rats, and groups restricted in energy intake by 20% or 40%. A second set of experiments involving both tumor models examined tumor growth in ad libitum fed rats or in animals whose energy intake was restricted by 30% using three different methods, i.e., total diet restriction, carbohydrate restriction, or lipid restriction. All P values are two-sided, Results: R3327-H tumors were smaller in energy-restricted or castrated rats than in control rats (P
