Nanotechnology in diagnosis and treatment of coronary artery disease.
Nanotechnology in diagnosis and treatment of coronary artery disease.
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DOI：
10.2217/nnm.16.3
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hamblin MR
中科院分区：
文献类型：
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作者：
Karimi M;Zare H;Bakhshian Nik A;Yazdani N;Hamrang M;Mohamed E;Sahandi Zangabad P;Moosavi Basri SM;Bakhtiari L;Hamblin MR
纳米技术可以提供一种新的补充方法来治疗冠状动脉疾病(CAD)，这种疾病现在是西方世界最大的杀手之一。导致动脉粥样硬化和冠心病的事件过程涉及许多生物因素和细胞疾病过程，这些过程可以通过纳米技术增强的治疗方法来缓解。纳米颗粒可以为药物和基因等货物提供各种输送系统，可以解决动脉内的许多问题。为了改善现有支架的性能，纳米技术除了提供可控释纳米载体外，还提供了不同的纳米材料涂层，以防止支架内再狭窄。纳米技术可以提高药物的效率，改善局部和系统地给药到动脉粥样硬化斑块，并减少血管内介入后的炎症或血管生成反应。纳米载体具有将成像和诊断试剂输送到精确目标目的地的潜力。本文综述了纳米技术在冠心病治疗中的应用现状和前景，以及主要的诊断方法。
Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.