Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer
Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer
复制标题
氧化还原活性氟化 5-羟基色氨酸作为生物电子转移分子报道分子的合成
DOI：
10.1039/d1cc00187f
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发表时间：
2021
影响因子：
4.9
通讯作者：
Haddy, Alice
中科院分区：
文献类型：
--
作者：
Ohler, Amanda;Long, Hanna;Ohgo, Kei;Tyson, Kristin;Murray, David;Davis, Amanda;Whittington, Chris;Hvastkovs, Eli G.;Duffy, Liam;Haddy, Alice
以克级量合成氟化的5-羟基吡喃（Fn-5 HOWs），并将其掺入β-发夹肽和蛋白质天青蛋白中。具有氧化还原活性的Fn-5 HOWs表现出独特的自由基光谱特征，扩展了5 HOW作为生物电子转移探针的功能。
Fluorinated 5-hydroxytryptophans (Fn-5HOWs) were synthesized in gram scale quantities and incorporated into a β-hairpin peptide and the protein azurin. The redox-active Fn-5HOWs exhibit unique radical spectroscopic signatures that expand the function of 5HOW as probes for biological electron transfer.