A viral caspase contributes to modified apoptosis for virus transmission
A viral caspase contributes to modified apoptosis for virus transmission
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DOI：
10.1101/gad.1300205
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发表时间：
2005-06-15
影响因子：
10.5
通讯作者：
Federici, BA
中科院分区：
文献类型：
--
作者：
Bideshi, DK;Tan, YP;Federici, BA
草地贪夜蛾子囊病毒是一种攻击鳞翅目昆虫的 DNA 病毒，编码感染 Sf21 细胞 9 小时后合成的刽子手半胱天冬酶。这种半胱天冬酶单独诱导昆虫细胞凋亡，并且在体内病毒复制过程中，有助于一种新的细胞裂解过程，在该过程中，正在发育的凋亡体被病毒拯救并分化形成大囊泡，病毒粒子在其中组装。这些病毒囊泡传播到血液中，在产卵过程中被传播病毒的寄生黄蜂获得。没有其他病毒编码半胱天冬酶或形成此类修饰的凋亡小体，这表明这种半胱天冬酶在促进病毒繁殖和传播的细胞划分中发挥直接作用。
The Spodoptera frugiperda ascovirus, a DNA virus that attacks lepidopterans, codes for an executioner caspase synthesized by 9 h after infection of Sf21 cells. This caspase alone induces apoptosis in insect cells and, during viral replication in vivo, contributes to a novel cell cleavage process in which developing apoptotic bodies are rescued by the virus and differentiate to form large vesicles in which virions assemble. These viral vesicles disseminate to the blood, where they are acquired during egg-laying by parasitic wasps that transmit the virus. No other viruses encode caspases or form such modified apoptotic bodies, suggesting this caspase plays a direct role in cell partitioning that facilitates viral reproduction and transmission.