A new strategy for specific eradication of implant-related infections based on special and selective degradability of rhenium trioxide nanocubes
A new strategy for specific eradication of implant-related infections based on special and selective degradability of rhenium trioxide nanocubes
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基于三氧化铼纳米立方体的特殊选择性降解性的特异性根除植入相关感染的新策略
DOI：
10.1021/acsami.9b07359
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发表时间：
2019
影响因子：
9.5
通讯作者：
Junqing Hu
中科院分区：
文献类型：
--
作者：
Wenlong Zhang;Chuang Yang;Ziyu Lei;Guoqiang Guan;Shu-ang He;Zhenbo Zhang;Rujia Zou;Hao Shen;Junqing Hu
光热抗菌治疗的最大瓶颈可能是难以直接加热感染部位，以避免对周围健康组织造成不必要的损害。近年来，人们越来越认识到感染性微环境（IMEs）是细菌感染的重要因素。本文报道了一种基于独特的ime和三氧化二铼（ReO3）纳米立方体（NCs）的新型光热抗菌策略。这些纳米碳纳米管是通过一种快速、直接的在衬底上限制空间的方法合成的，具有良好的生物相容性和高效的光热抗菌能力。特别是将其用于抗菌膜时，可有效抑制金黄色葡萄球菌的icaA、fnbA、atlE、sarA等生物膜相关基因的表达水平，阻断细菌粘附和生物膜的形成。重要的是，reo3nc可以在水环境中转化为氢铼青铜（HxReO3），使其在低pH的ime中相对稳定，用于光热治疗，同时在周围健康组织中迅速降解，以减少光热损伤。请注意，在pH为7.4的磷酸盐缓冲盐水（PBS）中，没有辅助条件，这些reo3nc在所有已知的可降解无机光热纳米剂中具有最高的降解率。reo3nc的这种特殊的、对ime敏感的选择性降解性不仅有助于安全、高效、特异性地消除植入物相关感染，而且还能在治疗后实现有效的身体清除。已报道的所有可降解无机光热纳米剂在PBS （pH 7.4）条件下，在没有任何辅助条件下，仅含有原子序数高于临床应用碘的元素（Re），具有高x射线衰减能力的ReO3NCs可进一步应用于x射线计算机断层成像引导治疗植入物相关感染。本文所述的工作是第一次采用可降解无机光热纳米剂来实现特异性抗菌治疗，并启发了这一概念的其他治疗方法。
The greatest bottleneck for photothermal antibacterial therapy could be the difficulty in heating the infection site directly and specifically to evade the unwanted damage for surrounding healthy tissues. In recent years, infectious microenvironments (IMEs) have been increasingly recognized as a crucial contributor to bacterial infections. Here, based on the unique IMEs and rhenium trioxide (ReO3) nanocubes (NCs), a new specific photothermal antibacterial strategy is reported. These NCs synthesized by a rapid and straightforward space-confined on-substrate approach have good biocompatibility and exhibit efficient photothermal antibacterial ability. Especially when they are utilized in antibiofilm, the expression levels of biofilm-related genes (icaA, fnbA, atlE, and sarA forStaphylococcus aureus) can be effectively inhibited to block bacterial adhesion and formation of biofilm. Importantly, the ReO3NCs can transform into hydrogen rhenium bronze (HxReO3) in an aqueous environment, making them relatively stable within the low pH of IMEs for photothermal therapy, while rapidly degradable within the surrounding healthy tissues to decrease photothermal damage. Note that under phosphate-buffered saline (PBS) at pH 7.4 without assistant conditions, these ReO3NCs have the highest degradation rate among all known degradable inorganic photothermal nanoagents. This special and IME-sensitive selective degradability of the ReO3NCs not only facilitates safe, efficient, and specific elimination of implant-related infections, but also enables effective body clearance after therapy. Solely containing the element (Re) whose atomic number is higher than clinic-applied iodine in all reported degradable inorganic photothermal nanoagents under the PBS (pH 7.4) without any assistant condition, the ReO3NCs with high X-ray attenuation ability could be further applied to X-ray computed tomography imaging-guided therapy against implant-related infections. The present work described here is the first to adopt degradable inorganic photothermal nanoagents to achieve specific antibacterial therapy and inspires other therapies on this concept.