Revealing the neural networks associated with processing of natural social interaction and the related effects of actor-orientation and face-visibility.
Revealing the neural networks associated with processing of natural social interaction and the related effects of actor-orientation and face-visibility.
复制标题
DOI：
10.1016/j.neuroimage.2013.09.046
复制
发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Reiss AL
中科院分区：
文献类型：
--
作者：
Saggar M;Shelly EW;Lepage JF;Hoeft F;Reiss AL
了解我们周围人的意图和愿望对于适应动态的社会环境至关重要。本文开发了一种新型的具有动态和自然刺激（2s视频片段）的事件相关功能磁共振成像（fMRI）范式，以直接检查与具有社交意图和非社交意图的手势处理相关的神经网络。当比较社会性和非社会性的姿态，增加激活的心智（或心理理论）和杏仁核网络被发现。作为第二个目标，演员取向的因素被纳入范式，以检查如何不同的神经机制，在社会交往中的个人参与与被动观察的互动。外侧枕叶皮层和中央前回的活动被发现在社会交往中对演员取向敏感。最后，通过操纵面部可见性，我们测试了面部信息是否是社交和非社交手势之间观察到的神经激活差异的主要驱动因素。我们发现后上级颞沟（pSTS）和梭状回（FFG）的活动部分是由观察社交手势时的面部表情驱动的。总之，使用与自然社会互动的处理相关的多个因素，我们在概念上推进我们对社会刺激如何在大脑中处理的理解，并讨论了这种范式在非典型社会认知表现为关键症状的临床人群中的应用。
Understanding the intentions and desires of those around us is vital for adapting to a dynamic social environment. In this paper, a novel event-related functional Magnetic Resonance Imaging (fMRI) paradigm with dynamic and natural stimuli (2s video clips) was developed to directly examine the neural networks associated with processing of gestures with social intent as compared to nonsocial intent. When comparing social to nonsocial gestures, increased activation in both the mentalizing (or theory of mind) and amygdala networks were found. As a secondary aim, a factor of actor-orientation was included in the paradigm to examine how the neural mechanisms differ with respect to personal engagement during a social interaction versus passively observing an interaction. Activity in the lateral occipital cortex and precentral gyrus were found sensitive to actor-orientation during social interactions. Lastly, by manipulating face-visibility we tested whether facial information alone is the primary driver of neural activation differences observed between social and nonsocial gestures. We discovered that activity in the posterior superior temporal sulcus (pSTS) and fusiform gyrus (FFG) were partially driven by observing facial expressions during social gestures. Altogether, using multiple factors associated with processing of natural social interaction, we conceptually advance our understanding of how social stimuli is processed in the brain and discuss the application of this paradigm to clinical populations where atypical social cognition is manifested as a key symptom.
登录
查看更多内容
影响因子：
1.7
作者：
Chan, AWY;Peelen, MV;Downing, PE
通讯作者：
Downing, PE
DOI：
10.1073/pnas.1013928108
发表时间：
2011-03-15
影响因子：
11.1
作者：
Collignon, Olivier;Vandewalle, Gilles;Lepore, Franco
通讯作者：
Lepore, Franco
影响因子：
5.7
作者：
Grezes, J.;Pichon, S.;de Gelder, B.
通讯作者：
de Gelder, B.
影响因子：
2
作者：
Knutson, Kristine M.;McClellan, Erin M.;Grafman, Jordan
通讯作者：
Grafman, Jordan
DOI：
10.1523/jneurosci.4268-09.2010
发表时间：
2010-05-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Golarai G;Hong S;Haas BW;Galaburda AM;Mills DL;Bellugi U;Grill-Spector K;Reiss AL
通讯作者：
Reiss AL