Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation.
Early life stress predicts negative urgency through brooding, depending on 5-HTTLPR genotype: A pilot study with 6-month follow-up examining suicide ideation.
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DOI：
10.1016/j.psychres.2017.08.092
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发表时间：
2017-12
影响因子：
11.3
通讯作者：
Miranda R
中科院分区：
文献类型：
--
作者：
Valderrama J;Miranda R
本研究探讨了早期生活压力和 5-HTT 基因型之间的相互作用，以预测随着时间的推移自杀行为的两个危险因素——沉思和冲动的亚型，以消极紧迫感的形式出现。此外，我们还研究了早期生活压力、沉思和冲动作为自杀意念随时间变化的预测因素。对有或没有早期生活压力史的参与者进行了 5-HTTLPR 多态性基因分型，并完成了评估基线和 6 个月随访时的沉思和消极紧迫感的评估。早年的情感虐待与随访时的消极紧迫感有关。我们发现，在 5-HTT 低表达基因型个体中，早期生活情感虐待通过沉思对消极紧迫感产生间接影响，但在 5-HTT 高表达基因型个体中则不然。此外，逻辑回归分析显示，负紧迫感与随访时报告自杀意念（相对于没有意念）的较高几率（OR = 16.2）相关。我们的研究结果表明，沉思和消极的紧迫感可能是由早期生活中的情感虐待和 5-HTT 低表达基因型之间的相互作用造成的。需要进一步的研究来了解早期生活压力如何与 5-HTT 基因型相互作用，从而通过心理机制赋予自杀行为的风险。
The present study examined the interaction between early life stress and 5-HTT genotypes in predicting two risk factors for suicidal behavior – the brooding subtype of rumination and impulsivity, in the form of negative urgency – over time. Furthermore, we examined early life stress, brooding, and impulsivity as predictors of suicidal ideation over time. Participants with and without a history of early life stress were genotyped for the 5-HTTLPR polymorphism and completed assessments assessing brooding and negative urgency at baseline and 6-month follow up. Early life emotional abuse was associated with negative urgency at follow-up. We found an indirect effect of early life emotional abuse on negative urgency through brooding among individuals with 5-HTT low expressing genotypes but not among individuals with 5-HTT high expressing genotypes. Further, a logistic regression analysis revealed that negative urgency was associated with higher odds (O.R. = 16.2) of reporting suicide ideation (versus no ideation) at follow-up. Our findings suggest that brooding and negative urgency may result from the interaction between early life emotional abuse and 5-HTT low expressing genotypes. Further research is necessary to understand how early life stress interacts with 5-HTT genotypes to confer risk for suicidal behavior through psychological mechanisms.
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