Classifying types of disseminated intravascular coagulation: clinical and animal models.
Classifying types of disseminated intravascular coagulation: clinical and animal models.
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DOI：
10.1186/2052-0492-2-20
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发表时间：
2014
影响因子：
7.1
通讯作者：
Asakura H
中科院分区：
文献类型：
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作者：
Asakura H
弥散性血管内凝血 (DIC) 具有共同的发病机制，即在存在基础疾病的情况下凝血持续广泛激活，但纤溶激活程度通常因 DIC 类型而异。纤溶抑制的 DIC 是脓毒症常见的 DIC 类型。凝血激活很严重，但纤溶激活很轻微。纤溶增强的 DIC 是常见于急性早幼粒细胞白血病 (APL) 的 DIC 类型。凝血激活和纤溶激活都很严重。平衡纤溶型DIC是实体瘤中常见的DIC类型，其发病机制介于上述两种类型之间。在动物DIC模型中，脂多糖（LPS）诱导的模型与抑制纤溶型DIC相似，而组织因子（TF）诱导的模型与增强纤溶/平衡纤溶型DIC相似。适当的诊断和治疗也可能因 DIC 类型而异。
Disseminated intravascular coagulation (DIC) has a common pathogenesis in terms of persistent widespread activation of coagulation in the presence of underlying disease, but the degree of fibrinolytic activation often differs by DIC type. DIC with suppressed fibrinolysis is a DIC type usually seen in sepsis. Coagulation activation is severe, but fibrinolytic activation is mild. DIC with enhanced fibrinolysis is a DIC type usually seen in acute promyelocytic leukemia (APL). Both coagulation activation and fibrinolytic activation are severe. DIC with balanced fibrinolysis is a DIC type usually seen in solid tumors, with an intermediate pathogenesis between the above two types. In animal DIC models, lipopolysaccharide (LPS)-induced models are similar to suppressed-fibrinolytic-type DIC, whereas tissue factor (TF)-induced models are similar to enhanced fibrinolytic/balanced fibrinolytic DIC. Appropriate diagnosis and treatment may also differ depending on the DIC type.