Impact of Dietary Intake of Medium-Chain Triacylglycerides on the Intestinal Absorption of Poorly Permeable Compounds
Impact of Dietary Intake of Medium-Chain Triacylglycerides on the Intestinal Absorption of Poorly Permeable Compounds
复制标题
膳食摄入中链三酰甘油对难渗透性化合物肠道吸收的影响
DOI：
10.1021/acs.molpharmaceut.9b00900
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发表时间：
2019
影响因子：
4.9
通讯作者：
Yamashita Shinji
中科院分区：
文献类型：
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作者：
Kataoka Makoto;Ohi Yuriko;Sakanoue Kana;Minami Keiko;Higashino Haruki;Yamashita Shinji
本研究旨在证明膳食摄入中链三酰甘油酯（MCT）对中等分子量渗透性差的化合物（FITC-右旋糖酐4000 [FD-4]）的肠道吸收的影响。作为MCT模型，主要使用C8-C12脂肪酸三酰甘油酯（COCONAD ML），并考虑饮食摄入剂量（12.5 mg/大鼠）设定每种甘油三酯的剂量规格。当将分散在禁食状态下的含表面活性剂的模拟肠液中的MCT的FD-4给予大鼠空肠时，FD-4的肠道吸收显著高于给予含或不含玉米油（长链甘油三酯）的类似溶液时。MCT脂解预处理、内源性脂肪酶抑制以及MCT和FD-4不同给药时间对FD-4肠吸收的影响表明，MCT在小肠中脂解释放的中链脂肪酸（如辛酸和癸酸）显著增强了FD-4的肠吸收，但这种作用是短暂的。此外，当MCT分散在豆浆中时，观察到类似的效果，尽管检测到较大的个体间差异。这些结果表明，MCT的饮食摄入可能会影响渗透性差的化合物的肠道吸收。
The present study sought to demonstrate the effect of dietary intake of medium-chain triacylglycerides (MCTs) on the intestinal absorption of a poorly permeable compound of intermediate molecular weight (FITC-dextran 4000 [FD-4]). As a model of MCTs, C8–C12fatty acid triacylglyceride (COCONAD ML) was mainly used, and the dose strength of each triglyceride was set with consideration of the dietary ingestion dose (12.5 mg/rat). When FD-4 with MCTs dispersed in fasted state simulated intestinal fluid containing surfactants was administered into the rat jejunum, the intestinal absorption of FD-4 was significantly higher than when administered with a similar solution with or without corn oil (long-chain triglycerides). The effects of pretreatment by MCT lipolysis, inhibition of endogenous lipases, and different dose timings of MCTs and FD-4 on the intestinal absorption of FD-4 indicated that medium-chain fatty acids, such as caprylic acid and capric acid, released from MCTs by lipolysis in the small intestine significantly enhanced the intestinal absorption of FD-4, but the effect was transient. In addition, a similar effect was observed when MCTs were dispersed in soymilk, although large interindividual variation was detected. These findings suggested that dietary intake of MCTs might affect the intestinal absorption of poorly permeable compounds.