Association of serum adiponectin with asthma and pulmonary function in the Japanese population
Association of serum adiponectin with asthma and pulmonary function in the Japanese population
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DOI：
10.1507/endocrj.ej14-0626
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发表时间：
2015-08-20
影响因子：
2
通讯作者：
Tobe, Kazuyuki
中科院分区：
文献类型：
--
作者：
Hayashikawa, Yasuko;Iwata, Minoru;Tobe, Kazuyuki
关于脂联素在哮喘中的作用，已有相互矛盾的研究结果报道。本研究的目的是评估日本人群脂联素与肺功能和哮喘的关系。首先，在参与先前研究的一般人群（第1组）中，排除患有哮喘、慢性阻塞性肺疾病和吸烟史的受试者后，我们选择了329名受试者，并检查了血清总脂联素水平与肺功能的关系。在由 61 名哮喘患者和 175 名对照非哮喘受试者组成的第二组（第 2 组）中，我们检查了哮喘与总、高 (HMW)、中 (MMW) 和低 (LMW) 分子量脂联素亚型水平以及每种亚型与总脂联素水平的比率之间的关联。尽管第 2 组中哮喘受试者和对照组受试者的总脂联素水平没有显着差异，但第 1 组中女性在调整混杂因素后，该水平与 1 秒用力呼气量呈显着正相关（P < 0.05）。在第 2 组中，调整混杂因素后，哮喘受试者的 LMW 脂联素水平显着高于对照受试者，而 MMW/总脂联素比率显着低于对照组。两性因素（P < 0.05）。本研究表明，低总脂联素水平可能导致与女性哮喘气道相一致的气道狭窄，而较高的LMW脂联素水平和较低的MMW/总脂联素比率与两性当前的哮喘显着相关。
Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim of this study was to evaluate the association of adiponectin with pulmonary functions and asthma in the Japanese population. First, among a general population that participated in a previous study (group 1), we selected 329 subjects after excluding those with asthma, chronic obstructive pulmonary disease, and a smoking history and examined the associations of the serum total adiponectin levels with pulmonary functions. In a second cohort (group 2) consisting of 61 asthmatic patients and 175 control non-asthmatic subjects, we examined the associations between asthma and the levels of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms as well as the ratio of each isoform to total adiponectin level. Although the total adiponectin levels were not significantly different between the asthmatic and control subjects in group 2, the levels were significantly and positively associated with the forced expiratory volume in 1 s after adjustments for confounding factors (P < 0.05) in women in group 1. In group 2, the LMW adiponectin level was significantly higher and the MMW/total adiponectin ratio was significantly lower among the asthmatic subjects than among the control subjects after adjustments for confounding factors in both sexes (P < 0.05). The present study showed that a low total adiponectin level may lead to airway narrowing compatible with asthmatic airways in women, and higher LMW adiponectin levels and lower MMW/total adiponectin ratio are significantly associated with current asthma in both sexes.