Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide.
Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide.
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新型环核苷酸核苷3,5-环硼烷硫代磷酸酯的合成。
DOI：
10.1039/b207350a
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Shaw,BarbaraRamsay
中科院分区：
文献类型：
--
作者：
Li,Ping;Shaw,BarbaraRamsay
首次合成了含硼双磷修饰的手性环核苷酸单磷酸盐(CNMP)，例如胸苷和5-氟-2‘-脱氧尿苷3’，5‘-环硼硫代硫酸盐，这些具有更高亲脂性的cNMP类似物可能成为潜在的抗癌前药和机制研究的有用探针。
The first examples of a borane-containing doubly P-modified chiral cyclic nucleoside monophosphate (cNMP), e.g., thymidine and 5-fluoro-2′-deoxyuridine 3′,5′-cyclic boranophosphorothioates, have been synthesized; these cNMP analogues with increased lipophilicity could be potential anticancer prodrugs and useful probes for mechanistic studies.