Use of dietary components to reduce bioaccessibility and bioavailability of cadmium in rice.
Use of dietary components to reduce bioaccessibility and bioavailability of cadmium in rice.
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DOI：
10.1021/acs.jafc.0c01582
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发表时间：
2020-03
影响因子：
6.1
通讯作者：
Shuo Sun;Xiaofang Zhou;Yingwen Li;Yongxing Li;H. Xia;Zhian Li;P. Zhuang
中科院分区：
文献类型：
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作者：
Shuo Sun;Xiaofang Zhou;Yingwen Li;Yongxing Li;H. Xia;Zhian Li;P. Zhuang
降低镉在体循环中的生物利用度是减少镉暴露的替代策略。采用离体胃肠道模型测定了39种膳食组分对水或大米中Cd生物可利用性的影响，然后采用体内生物测定法测定了对大米中Cd生物可利用性最有效的组分。结果表明，几种组分显著降低镉在肠相中的溶解度（10-98%）。单宁酸、TiO_2、葡萄糖酸锌、CaCl_2和原花青素对降低水稻Cd生物可利用性效果最好，分别降低93- 97%、54- 61%、32- 49%、24-32%和11- 14%。添加上述饲料成分后，镉在肾脏和肝脏中的相对生物利用度（Cd-RBA）分别降低20-58%和10-31%。这些结果可能对减少通过食用大米接触镉的健康风险具有重要意义。
Reducing Cd bioavailability in systemic circulation is an alternative strategy to reduce Cd exposure. The influence of 39 dietary components on Cd bioaccessibility in water or rice were determined using an in vitro gastrointestinal model, following which an in vivo bioassay was used to determine the most effective components on Cd bioavailability in rice. The results showed that several components significantly reduced the solubility of Cd (10-98%) in intestinal phase. Tannic acid, TiO2, zinc gluconate, CaCl2 and proanthocyanidins were the most effective in decreasing Cd bioaccessibility in rice, with reductions of 93-97%, 54-61%, 32-49%, 24-32% and 11-14%, respectively. Upon adding the dietary components, the reduction rates of the Cd-relative bioavailability (Cd-RBA) were 20-58% and 10-31% in the kidney and liver, respectively. The results may have important implications for reducing health risks associated with Cd exposure via consumption of rice.