A computerized approach for morphological analysis of the corpus callosum
A computerized approach for morphological analysis of the corpus callosum
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DOI：
10.1097/00004728-199601000-00017
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发表时间：
1996-01-01
影响因子：
1.3
通讯作者：
Bryan, RN
中科院分区：
文献类型：
--
作者：
Davatzikos, C;Vaillant, M;Bryan, RN
目的：提出一种分析胼胝体形态的新技术，并将其应用于一组老年受试者。材料和方法：所提出的方法使用弹性变形变换将受试者数据归一化到 Talairach 空间中。该变换的特性被用作关于 Talairach 图集的胼胝体形状的定量描述，该图集被视为标准。特别地，变形函数测量与该弹性变形相关的扩大/收缩。通过比较变形函数来进行受试者间比较。结果：该技术应用于八名男性受试者和八名女性受试者。根据每组的平均变形函数，发现女性胼胝体后部区域大于男性的相应区域。还发现了每组的平均胼胝体形状，直观地展示了该样本中两组之间的胼胝体形状差异。结论：所提出的方法利用了数据的完整分辨率，而不是依赖于面积测量等全局描述。将这种方法应用于老年群体表明胼胝体形状和大小存在性别相关差异。
Objective: A new technique for analyzing the morphology of the corpus callosum is presented, and it is applied to a group of elderly subjects.Materials and Methods: The proposed approach normalizes subject data into the Talairach space using an elastic deformation transformation. The properties of this transformation are used as a quantitative description of the callosal shape with respect to the Talairach atlas, which is treated as a standard. In particular, a deformation function measures the enlargement/shrinkage associated with this elastic deformation. Intersubject comparisons are made by comparing deformation functions.Results: This technique was applied to eight male and eight female subjects. Based on the average deformation functions of each group, the posterior region of the female corpus callosum was found to be larger than its corresponding region in the males. The average callosal shape of each group was also found, demonstrating visually the callosal shape differences between the two groups in this sample.Conclusion: The proposed methodology utilizes the full resolution of the data, rather than relying on global descriptions such as area measurements. The application of this methodology to an elderly group indicated sex-related differences in the callosal shape and size.