RISK-FACTORS FOR HIV-INFECTION AMONG DRUG-USERS IN YUNNAN PROVINCE, CHINA - ASSOCIATION WITH INTRAVENOUS DRUG-USE AND PROTECTIVE EFFECT OF BOILING REUSABLE NEEDLES AND SYRINGES
RISK-FACTORS FOR HIV-INFECTION AMONG DRUG-USERS IN YUNNAN PROVINCE, CHINA - ASSOCIATION WITH INTRAVENOUS DRUG-USE AND PROTECTIVE EFFECT OF BOILING REUSABLE NEEDLES AND SYRINGES
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DOI：
10.1097/00002030-199412000-00010
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发表时间：
1994-12-01
期刊：
影响因子：
3.8
通讯作者：
HOLMES, KK
中科院分区：
文献类型：
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作者：
XIA, MS;KREISS, JK;HOLMES, KK
目的：了解中国西南地区吸毒人群中HIV感染的流行情况及其相关因素。方法：采用横断面研究方法，对云南省龙岛村吸毒人员进行标准化访谈和自愿进行HIV血清学检测。以用药方法对潜在危险因素和保护因素进行分层分析。结果：182名参与者中，79名（43%）hiv -1血清阳性。64名静脉吸毒者（IVDU）中有51人（80%）呈HIV血清阳性，118名承认仅因吸烟而吸毒的人中有28人（24%）呈HIV血清阳性[优势比（OR）， 12.6；95%置信区间（CI）， 5.7-28.5]。在IVDU中，有报道称静脉用药前对可重复使用的注射器械进行煮沸消毒与显著的保护相关（校正OR为0.16；95% CI为0.03-0.87）。这种保护性关联在共享可重复使用注射设备的IVDU患者中也很重要。结论：云南省吸毒人群HIV感染与静脉吸毒高度相关。在中国和其他使用可重复使用注射设备的亚洲农村地区，通过煮沸对可重复使用注射设备进行灭菌的保护作用可以很容易地纳入IVDU的健康教育计划。
Objectives: To characterize the prevalence and correlates of HIV infection among drug users in southwestern China.Methods: Drug users in Longdao village, Yunnan Province underwent standardized interview and voluntary HIV serologic testing in a cross-sectional study. Analyses of potential risk and protective factors were stratified by method of drug use.Results: Of 182 participants, 79 (43%) were HIV-1-seropositive. HIV seropositivity was found in 51 (80%) of the 64 intravenous drug users (IVDU) and 28 (24%) of the 118 who acknowledged use of drugs only by smoking [odds ratio (OR), 12.6; 95% confidence interval (CI), 5.7-28.5]. Among IVDU, reported sterilization of reusable injection equipment by boiling before intravenous drug use was associated with significant protection (adjusted OR, 0.16; 95% CI, 0.03-0.87). This protective association was also significant among the subset of IVDU who shared reusable injection equipment.Conclusions: HIV infection among drug users in Yunnan Province was highly correlated with intravenous drug use. The protective effect of sterilization of reusable injection equipment by boiling could be easily integrated into health education programs among IVDU in China and other rural Asian settings where reusable injection equipment is used.