EEG source analysis of chronic fatigue syndrome
EEG source analysis of chronic fatigue syndrome
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DOI：
10.1016/j.pscychresns.2009.10.007
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发表时间：
2010-02-28
影响因子：
2.3
通讯作者：
Koles, Zoltan J.
中科院分区：
文献类型：
--
作者：
Flor-Henry, Pierre;Lind, John C.;Koles, Zoltan J.
对61例右偏、未服药的女性慢性疲劳综合征（CFS）患者进行了定量脑电图（43通道）研究。将患者的EEG与80名右侧健康女性对照的记录进行比较。只有那些受试者谁可以提供20 1-s伪影的EEG段被接纳进入研究。该分析包括识别的空间模式，最大限度地区分两组和这些模式的皮质源分布的估计脑电图。分析了α（8-13 Hz）和β（14-20 Hz）频段的空间模式，并使用Borgiotti-Kaplan BEAMFORMER算法估计了源分布。结果表明，所确定的空间模式是有效的分离两组，提供了一个最小的正确的回顾性分类率为72%，在两个频带，而受试者在休息到最大的83%，在阿尔法带在口头认知条件。两组在两个频段和所有认知条件下的底层皮层源分布均存在显著差异。在言语和空间认知条件下，两组在两个频带上的侧化皮层差异明显。在这些积极的认知条件下，CFS组显示出显着更大的源电流活动比对照组在左额颞顶叶区域的皮层。皇冠版权所有（C）2009由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Sixty-one dextral, unmedicated women with chronic fatigue syndrome (CFS) diagnosed according to the Fukuda criteria (1994) and referred for investigation by rheumatologists and internists were studied with quantitative EEG (43 channels) at rest with eyes open and during verbal and spatial cognitive activation. The EEGs from the patients were compared with recordings from 80 dextral healthy female controls. Only those subjects who could provide 20 1-s artefact-free segments of EEG were admitted into the study. The analysis consisted of the identification of the spatial patterns in the EEGs that maximally differentiated the two groups and the estimation of the cortical source distributions underlying these patterns. Spatial patterns were analyzed in the alpha (8-13 Hz) and beta (14-20 Hz) bands and the source distributions were estimated using the Borgiotti-Kaplan BEAMFORMER algorithm. The results indicate that the spatial patterns identified were effective in separating the two groups, providing a minimum correct retrospective classification rate of 72% in both frequency bands while the subjects were at rest to a maximum of 83% in the alpha band during the verbal cognitive condition. Underlying cortical source distributions showed significant differences between the two groups in both frequency bands and in all cognitive conditions. Lateralized cortical differences were evident between the two groups in the both frequency bands during both the verbal and spatial cognitive conditions. During these active cognitive conditions, the CFS group showed significantly greater source-current activity than the controls in the left frontal-temporal-parietal regions of the cortex. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.