Multiday recordings from olfactory bulb neurons in awake freely moving rats: Spatially and temporally organized variability in odorant response properties
Multiday recordings from olfactory bulb neurons in awake freely moving rats: Spatially and temporally organized variability in odorant response properties
复制标题
DOI：
10.1023/a:1008819818970
复制
发表时间：
1997-07-01
影响因子：
1.2
通讯作者：
Bower, JM
中科院分区：
文献类型：
--
作者：
Bhalla, US;Bower, JM
慢性单单位记录获得清醒的自由移动大鼠的嗅球的二尖瓣细胞层放置在气味流。在长达五天的时间内，从186个单个神经元中获得了618个记录。个别神经元的反应被认为是相当可变的，随着时间的推移，虽然这种变异性低于机会，并不是增量。附近神经元的反应比偶然预期的更相似，但比不同时间记录的单个神经元更不相似。然而，在空间上分开的神经元的反应更不同的机会在短时间内。在快速嗅闻过程中，单个单位的反应变得更加多变，反应的空间组织变得不那么明显。这些结果表明，嗅球中的神经元反应通常随着时间的推移而变化很大，这种变化在快速嗅探期间增加。这些结果被解释的上下文中的分布式，中央调制模型的嗅觉处理。
Chronic single-unit recordings were obtained from the mitral cell layer of the olfactory bulbs of awake freely moving rats placed in an odorant stream. Over periods up to five days, 618 recordings from 186 single neurons were obtained. Responses of individual neurons were found to be quite variable over time, although this variability was below chance and was not incremental. The responses of nearby neurons were more similar than expected by chance but less similar than individual neurons recorded at different times. However, responses of spatially well-separated neurons were more different than chance over short time periods. During rapid sniffing, single-unit responses became more variable, and the spatial organization of responses became less apparent. These results suggest that neuronal responses in the olfactory bulb are generally quite variable over time, with this variability increasing during periods of rapid sniffing. These results are interpreted in the context of a distributed, centrally modulated model of olfactory processing.