Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
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DOI：
10.1016/j.cmet.2016.12.022
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发表时间：
2017-02-07
期刊：
影响因子：
29
通讯作者：
Crawford PA
中科院分区：
文献类型：
--
作者：
Puchalska P;Crawford PA
酮体代谢是机体生理稳态的中心环节。在这篇综述中，我们讨论了酮如何在不同的营养状态下发挥离散的微调代谢作用，优化器官和生物体的性能，并保护多器官系统免受炎症和损伤。传统上被视为代谢底物，仅在碳水化合物限制中使用，最近的观察强调了酮体在碳水化合物丰富时作为重要的代谢和信号传导介质的重要性。作为对神经系统疾病已知治疗方案的补充，酮体在癌症中的前瞻性作用已经出现，在心脏和肝脏中具有有趣的保护作用，为肥胖相关和心血管疾病开辟了治疗方案。酮代谢和信号的争议进行了讨论，以调和与当代观察经典教条。
Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states, and protect from inflammation and injury in multiple organ systems. Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, recent observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations.