Serum Leptin as a Predictor of Fatty Liver in 7-Year-Old Korean Children
Serum Leptin as a Predictor of Fatty Liver in 7-Year-Old Korean Children
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DOI：
10.1159/000165360
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发表时间：
2008-01-01
影响因子：
3.9
通讯作者：
Song, Jihyun
中科院分区：
文献类型：
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作者：
Kim, In Kyoung;Kim, Jihye;Song, Jihyun
目的：本研究探讨血清瘦素作为韩国儿童脂肪肝疾病预测指标的有效性。方法：从韩国城市地区招募124名儿童。测量了人体测量参数和临床变量，如血脂、胰岛素和瘦素水平。肝超声检查脂肪肝。我们还使用24小时饮食回忆法收集了3天的饮食摄入数据。超重儿童是根据国际肥胖工作组制定的标准确定的。结果：所有儿童的脂肪肝患病率为12.1%，超重儿童的脂肪肝患病率明显高于正常儿童（22.5% vs. 7.1%, p < 0.05）。在正常体重儿童中，脂肪肝儿童的血清瘦素水平是健康肝脏儿童的2倍（分别为6.2和2.9 ng/ml, p < 0.05）。在超重儿童中，有脂肪肝的儿童血清瘦素水平升高。多元logistic回归分析显示，血清瘦素与脂肪肝疾病密切相关，与体重指数无关。在有脂肪肝和没有脂肪肝的儿童中，能量和脂肪摄入量、水果和蔬菜摄入量的频率以及体育活动的频率没有差异。结论：血清瘦素升高可能是筛查儿童早期脂肪肝的有用指标。版权所有2008 S. Karger AG，巴塞尔
Aim: This study investigated the usefulness of serum leptin as a predictor of fatty liver disease in Korean children. Methods: One hundred and twenty-four children were recruited from urban areas in Korea. Anthropometrical parameters and clinical variables, such as the levels of serum lipids, insulin and leptin, were measured. Fatty liver disease was detected via hepatic sonogram. We also collected dietary intake data using a 24-hour dietary recall for 3 days. Overweight children were identified using the standards established by the International Obesity Task Force. Results: The prevalence of fatty liver disease was 12.1% among all children and was significantly higher in overweight than in normal children (22.5 vs. 7.1%, respectively; p < 0.05). Within normal weight children, children with fatty livers showed a 2-fold increase in serum leptin levels compared with children with healthy livers (6.2 vs. 2.9 ng/ml, respectively; p < 0.05). Within overweight children, elevated serum leptin levels were observed in children with fatty livers. Multiple logistic regression analysis revealed that serum leptin was strongly associated with fatty liver disease, independent of the body mass index. Energy and fat intake, the frequency of fruit and vegetable consumption, and the frequency of physical activity did not differ among children with or without fatty livers. Conclusion: Elevated serum leptin may be a useful parameter when screening for early fatty liver disease among children. Copyright (C) 2008 S. Karger AG, Basel