Widespread expression of GABAA receptor subunits in peripheral tissues
Widespread expression of GABAA receptor subunits in peripheral tissues
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DOI：
10.1016/s0168-0102(99)00078-4
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发表时间：
1999-11-01
影响因子：
2.9
通讯作者：
Schofield, PC
中科院分区：
文献类型：
--
作者：
Akinci, MK;Schofield, PC
γ -氨基丁酸（GABA）在外周和内分泌组织中参与其生理药理作用的受体亚型尚不清楚。关于外周内分泌组织中GARA(A)受体的分子特征的信息仅适用于胰腺和肾上腺髓质。利用逆转录（RT）聚合酶链反应（PCR），显示了GABA(A)受体亚基在大鼠外周组织中的广泛表达，包括肾上腺、卵巢、睾丸、胎盘、子宫和小肠。结果表明，GABA(A)受体亚基在多种内分泌组织中以组织特异性的方式表达。这些结果对这些组织中GABA(A)受体可能的药理学特性有了深入的了解。与肾上腺相比，胎盘、卵巢、睾丸等性腺内分泌组织表达GABA(A)受体亚基的范围更广。平滑肌含量较高的组织、小肠和子宫表达的亚单位亚型范围也较小。1999爱思唯尔科学爱尔兰有限公司版权所有。
The receptor subtypes involved in the physiological and pharmacological actions of gamma-amino butyric acid (GABA) in peripheral and endocrine tissues are not clear. Information about the molecular characteristics of GARA(A) receptors in peripheral endocrine tissues is only available for the pancreas and the adrenal medulla. Using reverse transcription (RT) polymerase chain reaction (PCR), the widespread expression of GABA(A) receptors subunits in rat peripheral tissues, including adrenal, ovary, testis, placenta, uterus, and small intestine is shown. It is shown that GABA(A) receptor subunits are expressed in multiple endocrine tissues in a tissue specific manner. These results give an insight into the likely pharmacological properties of these GABA(A) receptors in these tissues. The gonadal endocrine tissues such as the placenta, ovary and the testis express greater range of GABA(A) receptor subunits relative to the adrenal gland. The tissues with greater smooth muscle content, the small intestine and the uterus also express a smaller range of subunits subtypes. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.