Establishment of framework of the cortical area is influenced by Otx1
Establishment of framework of the cortical area is influenced by Otx1
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DOI：
10.1016/j.neures.2008.01.002
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发表时间：
2008-04-01
影响因子：
2.9
通讯作者：
Sato, Makoto
中科院分区：
文献类型：
--
作者：
Ando, Koichi;Yagi, Hideshi;Sato, Makoto
皮质下投射来自第5层神经元是主要的皮质输出。转录因子Otx 1在视皮层的第5层皮层下投射神经元中表达，据报道，它通过诱导感觉运动皮层采用视觉皮层身份来负责建立视觉区域特异性的第5层皮层下投射。然而，我们在这里表明，该地区的皮质脊髓神经元转移caudo-medialally在Otx 1-null小鼠的皮质是十分之九的大小相比，野生型同窝仔，而整个视觉皮层没有转换为感觉运动皮层的情况下，Otx 1。这表明，Otx 1是不是至关重要的视觉皮层身份的发展，但对确定的比例，整个新皮层的皮质区。(C)2008年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Subcortical projection from layer 5 neurons is the major cortical output. A transcription factor, Otx1, which is expressed in the layer 5 subcortical projection neurons in the visual cortex, was reported to be responsible for the establishment of visual area-specific layer 5 subcortical projections by inducing the sensorimotor cortex to adopt a visual cortex identity. However, we here demonstrate that the area of corticospinal neurons shifted caudo-medially in the Otx1-null mice of which cortex is 9 tenths in size compared with that of the wild-type littermates, while the whole visual cortex did not convert to the sensorimotor cortex in the absence of Otx1. This suggests that Otx1 is not crucial for the development of visual cortex identity but for the determination of the proportion of cortical areas to the whole neocortex. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.