MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction
MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction
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MnBr2 催化区域特异性氧化 Mizoroki-Heck 型反应。
DOI：
10.1016/j.cclet.2021.10.083
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发表时间：
2022-04-27
影响因子：
9.1
通讯作者：
Shen, Xiao
中科院分区：
文献类型：
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作者：
Chen, Xiang;Zhu, Zhihong;Shen, Xiao
本文报道了一个前所未有的区域特异性氧化Mizoroki-Heck型反应合成α-二氟甲基高烯丙醇。该反应具有较宽的底物范围和较高的官能团耐受性。复杂的生物活性分子的后期功能化证明了这种转化的合成潜力。机理研究支持MnBr 2催化的自由基1，2-甲硅烷基转移的参与。(C)2021由Elsevier B. V.代表中国化学会和中国医学科学院药物研究所出版。
Herein, we report an unprecedented regiospecific oxidative Mizoroki-Heck type reaction for the synthesis of alpha-difluoromethyl homoallylic alcohols. The reaction shows broad substrate scopes and high functional group tolerance. Late-stage functionalization of complex biologically active molecules demonstrates the synthetic potential of this transformation. Mechanistic study supports the involvement of MnBr2 catalyzed radical 1,2-silyl transfer. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.