Cross-regulation of Pseudomonas motility systems: the intimate relationship between flagella, pili and virulence.
Cross-regulation of Pseudomonas motility systems: the intimate relationship between flagella, pili and virulence.
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DOI：
10.1016/j.mib.2015.07.017
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发表时间：
2015-12
影响因子：
5.4
通讯作者：
Jain R
中科院分区：
文献类型：
--
作者：
Kazmierczak BI;Schniederberend M;Jain R
铜绿假单胞菌使用两种不同的运动形式进行导航：游泳和抽搐。极鞭毛和 4 型菌毛分别为这些运动提供动力，使铜绿假单胞菌能够附着在表面并定殖。单细胞成像和粒子跟踪算法揭示了多种细菌表面行为，这些行为受到第二信使环二 GMP 和 cAMP 的调节；这些信号的产生反过来对运动细胞器与表面的接触做出反应。先天免疫防御系统长期以来已知能够识别鞭毛的结构成分，似乎对运动本身做出反应。运动性与毒力上调和宿主防御机制诱导的关联是鞭毛和菌毛对铜绿假单胞菌发病机制的复杂贡献的基础。
Pseudomonas aeruginosa navigates using two distinct forms of motility, swimming and twitching. A polar flagellum and Type 4 pili power these movements, respectively, allowing P. aeruginosa to attach to and colonize surfaces. Single cell imaging and particle tracking algorithms have revealed a wide range of bacterial surface behaviors which are regulated by second messengers cyclic-di-GMP and cAMP; the production of these signals is, in turn, responsive to the engagement of motility organelles with a surface. Innate immune defense systems, long known to recognize structural components of flagella, appear to respond to motility itself. The association of motility with both upregulation of virulence and induction of host defense mechanisms underlies the complex contributions of flagella and pili to P. aeruginosa pathogenesis.