The implications of telomerase biochemistry for human disease
The implications of telomerase biochemistry for human disease
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DOI：
10.1016/s0959-8049(97)00061-0
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发表时间：
1997-04-01
影响因子：
8.4
通讯作者：
Morin, GB
中科院分区：
文献类型：
--
作者：
Morin, GB
传统DNA聚合酶无法完全复制线性染色体末端（端粒）。端粒酶是大多数真核生物用来解决端粒末端复制问题的特殊DNA聚合酶。端粒酶对于大多数永生细胞的无限期细胞分裂是必需的，但对于大多数体细胞组织的正常功能显然不是必需的。端粒酶可能在一些遗传疾病、调节正常细胞的寿命以及肿瘤发生中发挥关键作用。本文综述了哺乳动物端粒酶的结构和反应机制，以及如何利用它来控制一些人类疾病。 (C) 1997 爱思唯尔科学有限公司。
The replication of linear chromosome termini (telomeres) cannot be completely replicated by conventional DNA polymerases. Telomerase is a special DNA polymerase used by most eukaryotes to solve the telomere end replication problem. Telomerase is necessary for indefinite cell division in most immortal cells, but apparently unnecessary for the normal function of most somatic tissues. Telomerase may play a critical role in some genetic diseases, in regulating the lifespan of normal cells, and in tumorigenesis. This article reviews the structure and reaction mechanism of mammalian telomerase and how it may be exploited to control some human diseases. (C) 1997 Elsevier Science Ltd.