Short‐term disappearance of muscarinic cell surface receptors in carbachol‐induced desensitization
Short‐term disappearance of muscarinic cell surface receptors in carbachol‐induced desensitization
复制标题
卡巴胆碱诱导的脱敏中毒蕈碱细胞表面受体的短期消失
DOI：
10.1016/0014-5793(83)80257-9
复制
发表时间：
1983
期刊：
影响因子：
3.5
通讯作者：
P. Laduron
中科院分区：
文献类型：
--
作者：
J. Maloteaux;A. Gossuin;P. Pauwels;P. Laduron
在完整的108CC15杂交瘤细胞和大鼠小脑细胞上，以[~3H]甲基东莨菪碱为配基，卡巴胆碱可引起细胞表面M受体的快速消失。这种现象是温度依赖的，与激动剂刺激相关，并且是可逆的。在这些短时间内(⩽30min)，膜制剂上测得的总受体数量没有变化。这种细胞表面受体的消失可能是细胞脱敏的第一个事件，紧随其后的是生理条件下的受体回收，或者如果激动剂的刺激持续存在，则可能是受体降解，如在长期调节中。
A rapid carbachol-induced disappearance of muscarinic cell surface receptors was shown using [3H]methyl scopolamine as ligand on intact 108CC15 hybrid cells or rat cerebellar cells. This phenomenon is temperature-dependent, correlated to agonist stimulation and reversible. In these short time periods (⩽30 min), no change was observed in the total receptor amount measured on membrane preparations. This disappearance of cell surface receptors could represent the first event in cell desensitization which could be followed by receptor recycling in physiological conditions or by receptor degradation if the stimulation by agonists persists, as in long-term regulation.
影响因子：
5.8
作者：
Richelson,E;El-Fakahany,E
通讯作者：
El-Fakahany,E