Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery
Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of delivery
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DOI：
10.1007/s00737-011-0239-x
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发表时间：
2011-12-01
影响因子：
4.5
通讯作者：
Skalkidou, Alkistis
中科院分区：
文献类型：
--
作者：
Comasco, Erika;Sylven, Sara M.;Skalkidou, Alkistis
产后抑郁症（PPD）是一种经常被诊断和治疗不足的情绪障碍，对母亲和婴儿的健康产生负面影响。季节性变化被认为是PPD的一个危险因素。候选基因，如编码脑源性神经营养因子（BDNF）、5-羟色胺转运蛋白（5-HTT）和Period 2（PER 2）的基因，与抑郁症和季节性疾病有关。本研究的目的是检查是否功能性多态性变体，BDNF Val 66 Met，5-HTTLPR，或PER 2 SNP 10870，与PPD症状，以及这些遗传多态性是否与季节相互作用，预测PPD症状。这项病例对照研究包括275名来自瑞典分娩妇女群体的妇女，她们在产后6周和6个月完成了一份包含爱丁堡产后抑郁量表（EPDS）的问卷。压力性生活事件（SLEs）和产妇压力源也进行了评估。结果没有显示任何统计学显着的研究遗传多态性和PPD症状之间的整体关联。然而，BDNF Met 66载体状态和产后6周PPD症状的发展之间的显着关联，即使在控制产后和产后环境危险因素时，在秋季/冬季分娩的母亲中也是明显的。没有发现基因-基因相互作用，但检测到累积效应，如果在秋季/冬季分娩，携带更多5-HTTLPR S和BDNFVal 66 Met Met等位基因的患者报告更高的EPDS评分。我们的研究结果提出了BDNF基因在PPD症状发展中的作用，可能由分娩季节介导。
Postpartum depression (PPD) is an often underdiagnosed and undertreated mood disorder, with negative impact on the mother's and infant's health. Seasonal variation has been discussed as a risk factor for PPD. Candidate genes, such as those encoding for the brain-derived neurotrophic factor (BDNF), serotonin transporter (5-HTT), and Period2 (PER2), have been associated with depression and seasonal disorders. The present study is aimed to examine whether functional polymorphic variants, BDNF Val66Met, 5-HTTLPR, or PER2 SNP 10870, are associated with PPD symptoms and whether these genetic polymorphisms interact with season in predicting PPD symptoms. This case-control study comprised of 275 women from a population-based cohort of delivering women in Sweden, who completed a questionnaire containing the Edinburgh postnatal depression scale (EPDS) at 6 weeks and 6 months postpartum. Stressful life events (SLEs) and maternity stressors were also assessed. The results did not reveal any statistically significant overall association between the studied genetic polymorphisms and PPD symptoms. However, a significant association between BDNF Met66 carrier status and development of PPD symptoms at 6 weeks postpartum, even when controlling for prepartum and postpartum environmental risk factors, was evident among mothers delivering during autumn/winter. No gene-gene interactions were found but a cumulative effect was detected with carriers of a greater number of 5-HTTLPR S and BDNFVal66Met Met alleles reporting higher EPDS scores, if delivered during autumn/winter. Our findings propose a role of the BDNF gene in the development of PPD symptoms, potentially mediated by season of delivery.