Changes in serum albumin and α1‐acid glycoprotein concentrations during pregnancy: an analysis of fetal‐maternal pairs
Changes in serum albumin and α1‐acid glycoprotein concentrations during pregnancy: an analysis of fetal‐maternal pairs
复制标题
妊娠期间血清白蛋白和α1-酸性糖蛋白浓度的变化：胎儿-母体对的分析
DOI：
10.1111/j.1471-0528.1984.tb03700.x
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Anner
中科院分区：
文献类型：
--
作者：
B. Krauer;P. Dayer;R. Anner
总结。在妊娠12 ~ 41周的44对胎儿和母亲血清样本中，测定了两种主要的药物结合蛋白白蛋白和α1 -酸性糖蛋白的浓度。在此期间，母亲血清白蛋白浓度在25至35 g/1之间。胎儿血清白蛋白在妊娠早期要低得多，在12 ~ 15周时为7.5 ~ 16 g/1。随着年龄的增长，血清白蛋白浓度呈线性增长，在30周时，胎儿和母亲的血清白蛋白浓度在同一范围内，35周后，胎儿的血清白蛋白浓度超过母亲约20%。因此，平均胎/母血清白蛋白浓度比从妊娠早期到足月增加：12-15周时0.38；16-25周0.66；26 ~ 35周0.97；妊娠35周时为1.2。孕妇血清α1 -酸性糖蛋白浓度分布在0.38 ~ 1.05 g/l之间。使用该技术，胎儿血清浓度在16周之前几乎无法检测到。此后，他们以恒定的速度增长，但从未达到母亲的价值。近期胎母血清浓度比为0.37。这些蛋白质浓度的变化可能具有重要的药理学意义。
Summary. The concentration of the two principal drug‐binding proteins, albumin and α1‐acid glycoprotein, were measured in 44 paired fetal and maternal serum samples obtained at between 12 and 41 weeks gestation. Maternal serum albumin concentrations ranged between 25 and 35 g/1 during this period. Fetal serum albumin was much lower in early gestation, ranging from 7.5 to 16 g/1 at 12 ‐ 15 weeks. With advancing age there was a linear increase so that at 30 weeks the fetal and the maternal serum albumin concentrations were in the same range and after 35 weeks the fetal concentrations exceeded the maternal by some 20%. Thus, the mean fetal/maternal serum concentration ratio of albumin increases from early pregnancy to term: 0.38 at 12–15 weeks; 0.66 at 16–25 weeks; 0.97 at 26–35 weeks; and 1.2 at >35 weeks gestation. Maternal serum α1‐acid glycoprotein concentrations were scattered widely between 0.38 and 1.05 g/l. With the technique used fetal serum concentrations were hardly detectable before 16 weeks. Thereafter they increased at a constant rate, but never attained the maternal values. Near term a fetal/maternal serum concentration ratio of 0.37 was reached. These changes in protein concentrations may have important pharmacological implications.