DENERVATED HUMAN SKELETAL-MUSCLE - MR IMAGING EVALUATION
DENERVATED HUMAN SKELETAL-MUSCLE - MR IMAGING EVALUATION
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DOI：
10.1148/radiology.187.1.8451416
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发表时间：
1993-04-01
期刊：
影响因子：
19.7
通讯作者：
PURDY, PD
中科院分区：
文献类型：
--
作者：
FLECKENSTEIN, JL;WATUMULL, D;PURDY, PD
由于严重肢体创伤后神经功能完整性的确定在患者护理中至关重要，作者评估了磁共振（MR）成像作为创伤性周围神经病患者骨骼肌失神经运动单位标测的工具。22例患者通过肌电图、手术或两者联合证实了去神经。MR成像采用中等T1和T2加权自旋回波和短tau反转恢复（STIR）序列。磁共振成像是不可靠的描绘急性失神经支配。亚急性失神经支配患者的肌肉T1和T2延长，导致STIR图像上明显的高信号。慢性失神经支配的肌肉表现出明显的萎缩，STIR图像上的变化，T1加权图像上的脂肪浸润明显。在运动单位解剖的正常变异被认为是在失神经肌肉体积外的预期分布的损伤神经。磁共振成像是有前途的非侵入性映射和监测失神经肌肉在亚急性和慢性阶段的周围神经病变。
Because determination of neurologic integrity after severe limb trauma is crucial in patient care, the authors assessed magnetic resonance (MR) imaging as a tool to map denervated motor units of skeletal muscle in patients with tramatic peripheral neuropathy. Denervation was confirmed in 22 patients with use of electromyography, surgery, or both. MR imaging was performed with moderately T1- and T2-weighted spin-echo and short-tau inversion-recovery (STIR) sequences. MR imaging was unreliable in depicting acute denervation. Muscles of patients with subacute denervation had prolonged T1 and T2, which contributed to conspicuous hyperintensity on STIR images. Chronically denervated muscles showed marked atrophy, variable changes on STIR images, and conspicuous fatty infiltration on T1-weighted images. Normal variants in motor unit anatomy were seen in denervated muscle volumes outside the expected distribution of the injured nerve. MR imaging is promising for the noninvasive mapping and monitoring of denervated muscle in subacute and chronic phases of peripheral neuropathy.