Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats.
Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats.
复制标题
胰淀素和胆囊收缩素对大鼠食物摄入和胃排空的比较影响。
DOI：
10.1152/ajpregu.2001.280.3.r605
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Permert,J
中科院分区：
文献类型：
--
作者：
Reidelberger,RD;Arnelo,U;Granqvist,L;Permert,J
CCK is a physiological inhibitor of gastric emptying and food intake. The pancreatic peptide amylin exerts similar actions, yet its physiological importance is uncertain. Objectives were to compare the dose-dependent effects of intravenous infusion of amylin and CCK-8 on gastric emptying and food intake in rats, and to assess whether physiological doses of amylin are effective. Amylin and CCK-8 inhibited gastric emptying with mean effective doses (ED50s) of 3 and 35 pmol · kg−1· min−1and maximal inhibitions of 60 and 65%, respectively. Amylin and CCK-8 inhibited food intake with ED50s of 8 and 14 pmol · kg−1· min−1and maximal inhibitions of 78 and 69%, respectively. The minimal effective amylin dose for each effect was 1 pmol · kg−1· min−1. Our previous work suggests that this dose increases plasma amylin by an amount comparable to that produced by a meal. These results support the hypothesis that amylin acts as a hormonal signal to the brain to inhibit gastric emptying and food intake and that amylin produces satiety in part through inhibition of gastric emptying.
