Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial
Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial
复制标题
DOI：
10.1007/s00134-018-5433-0
复制
发表时间：
2018-12-01
影响因子：
38.9
通讯作者：
Mukherjee, Ashes
中科院分区：
文献类型：
--
作者：
Macdonald, Stephen P. J.;Keijzers, Gerben;Mukherjee, Ashes
目的确定与常规护理相比，限制液体和早期升压药方案对于疑似脓毒症所致低血压的初始复苏是否可行。方法对急诊科 (ED) 疑似脓毒症且收缩压低于 100mmHg 的患者进行至少 1000ml 静脉输液后，在前 6 小时内进行限制性液体复苏方案的前瞻性、随机、开放性临床试验。主要结果是随机分组后 6 小时内给予的总液体量。 结果 意向治疗分析中有 99 名参与者（50 名限制容量和 49 名常规护理）。限制容量组中从就诊到 6 小时的中位容量为 2387ml [第一至第三四分位数 (Q1-Q3) 1750-2750ml]； 30ml/kg（Q1-Q3 32-39ml/kg）对比3000ml（Q1-Q3 2250-3900ml）；常规护理组43ml/kg（Q1-Q3 35-50ml/kg）（p
PurposeTo determine if a regimen of restricted fluids and early vasopressor compared to usual care is feasible for initial resuscitation of hypotension due to suspected sepsis.MethodsA prospective, randomised, open-label, clinical trial of a restricted fluid resuscitation regimen in the first 6h among patients in the emergency department (ED) with suspected sepsis and a systolic blood pressure under 100mmHg, after minimum 1000ml of IV fluid. Primary outcome was total fluid administered within 6h post randomisation.ResultsThere were 99 participants (50 restricted volume and 49 usual care) in the intention-to-treat analysis. Median volume from presentation to 6h in the restricted volume group was 2387ml [first to third quartile (Q1-Q3) 1750-2750ml]; 30ml/kg (Q1-Q3 32-39ml/kg) vs. 3000ml (Q1-Q3 2250-3900ml); 43ml/kg (Q1-Q3 35-50ml/kg) in the usual care group (p