Effects of a continuous infusion of dopamine on the ventilatory and carotid body responses to hypoxia in cats.
Effects of a continuous infusion of dopamine on the ventilatory and carotid body responses to hypoxia in cats.
复制标题
连续输注多巴胺对猫通气和颈动脉体对缺氧反应的影响。
DOI：
10.1111/j.1440-1681.1995.tb02084.x
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发表时间：
1995
影响因子：
2.9
通讯作者：
Fitzgerald,RS
中科院分区：
文献类型：
--
作者：
Ide,T;Shirahata,M;Chou,CL;Fitzgerald,RS
1.我们研究了临床上常用的多巴胺（DA; 5μg/kg/min）的持续输注如何影响麻醉猫的通气和颈动脉化学感受器神经活动。在麻醉、自主呼吸的猫上，在五个吸氧水平（P_（10）= 110、130、150、170、760 mmHg）下，连续监测Da或生理盐水输注时的潮气量（Vt）和呼吸频率（f）。暴露于各水平的P102 3 min后，对Vt和f采样1 min。并进行时间对照研究.在常氧和缺氧条件下，DA输注显著降低了8只猫中的7只猫的VT。呼吸频率不受DA输注的影响。DA输注增强了缺氧后高氧期间的通气抑制。去化学神经可使缺氧诱导的兴奋性反应消失，DA对缺氧诱导的兴奋性反应无进一步影响.在第二组人工通气猫，颈动脉化学感受器神经活动记录在五个水平的动脉氧分压。DA输注显着抑制颈动脉化学感受器神经活动在常氧和缺氧的7只猫中的6。这些结果表明，在低剂量DA输注期间通气的变化与颈动脉体神经输出密切相关。该剂量DA（5 μg/kg/min）的主要作用是由于抑制颈动脉体神经输出而抑制对缺氧的反应。
1. We investigated how a continuous infusion of dopamine (DA; 5μg/kg per min), which is often used clinically, would affect the ventilation and carotid chemoreceptor neural activity in anaesthetized cats.2. In anaesthetized, spontaneously breathing cats, tidal volume (Vt) and respiratory frequency (f) were continuously monitored at five levels of inspired oxygen (P102= 110,130, 150, 170, 760mmHg) during Da or saline infusion. Vt and f were sampled for 1 min after 3 min exposure to each level of P102. Time control study was also performed.3. DA infusion significantly lowered VTunder both normoxia and hypoxia in seven of eight cats. Respiratory frequency was not affected by DA infusion. Depression of ventilation during post‐hypoxic hyperoxia was augmented by DA infusion. Chemodenervntion abolished the ventilatory response to hypoxia and DA did not further affect the ventilatory response to hypoxia.4. In a second group of artificially ventilated cats, carotid chemoreceptor neural activity was recorded at five levels of arterial oxygen tension. DA infusion significantly depressed carotid chemoreceptor neural activity during normoxia and hypoxia in six of seven cats.5. These findings suggest that changes in ventilation during low dosage of DA infusion closely correlate with carotid body neural output. A predominant effect of this dosage of DA (5 μg/kg per min) was depression in the ventilatory response to hypoxia due to an inhibition of carotid body neural output.