Diluted tincture of opium (DTO) and phenobarbital versus DTO alone for neonatal opiate withdrawal in term infants
Diluted tincture of opium (DTO) and phenobarbital versus DTO alone for neonatal opiate withdrawal in term infants
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DOI：
10.1067/mpd.2002.123099
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Lester, B
中科院分区：
文献类型：
--
作者：
Coyle, MG;Ferguson, A;Lester, B
目的：本研究的目的是检验这一假设，即治疗新生儿阿片类药物戒断（NOW）在足月婴儿稀释酊的鸦片（DTO）和苯巴比妥是上级治疗DTO单研究设计：这是一个部分随机，对照试验，其中20个足月婴儿暴露于美沙酮和/或海洛因在子宫内进行了研究。采用Finnegan评分系统评估NOW的严重程度。当需要药物治疗时，婴儿被分配到DTO和安慰剂组（n = 10）或DTO和苯巴比妥组（n = 10）。主要结局变量为住院时间。退出和住院费用的严重程度是次要结局variables.Results：有没有显着差异，在胎龄，生长变量，母亲美沙酮剂量，或年龄在两组之间的登记。住院时间缩短48%（79-38天）（P
Objective: The purpose of this study was to test the hypothesis that treatment of neonatal opiate withdrawal (NOW) in the term infant with diluted tincture of opium (DTO) and phenobarbital was superior to treatment with DTO alone.Study design: This was a partially randomized, controlled trial in which 20 term infants exposed to methadone and/or heroin in utero were studied. The severity, of NOW was assessed by using the Finnegan scoring system. Infants were assigned to either DTO and placebo (n = 10) or DTO and phenobarbital (n = 10) when medication was required. The primary outcome variable was the duration of hospitalization. Severity of withdrawal and hospital cost were secondary outcome variables.Results: There were no significant differences in the gestational age, growth variables, maternal methadone dose, or age at enrollment between the 2 groups. The duration of hospitalization was reduced by 48% (79-38 days) (P