EFFECTS OF SCHEDULED ACCESS ON ETHANOL INTAKE BY THE ALCOHOL-PREFERRING (P) LINE OF RATS
EFFECTS OF SCHEDULED ACCESS ON ETHANOL INTAKE BY THE ALCOHOL-PREFERRING (P) LINE OF RATS
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DOI：
10.1016/0741-8329(86)90010-8
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发表时间：
1986-09-01
期刊：
影响因子：
2.3
通讯作者：
LI, TK
中科院分区：
文献类型：
--
作者：
MURPHY, JM;GATTO, GJ;LI, TK
在三种条件下检查了乙醇可用性对选择性饲养的偏好酒精的P大鼠自愿消费的影响：不受限制的24小时/天的访问（条件A），访问限制为连续4小时/天（条件B），和访问限制为每3小时1小时，4次/天（条件C）。食物和水总是可用的。每日酒精摄入量（平均值±）SEM）为6.9 ±。0.2，2.1 . ±. 0.2和4.4 .+-。0.2 g/kg，而每小时的摄入量从0.3 . ±. 0.03在条件A至1.1 .+-下。0.4 g/kg。在条件A、B和C下，每次饮酒消耗的乙醇量为1.1 ± 1.5。0.1，2.1 . ±. 0.2和1.1 .+-。0.03 g/kg。在条件A的黑暗周期期间和在条件B和C下饮酒事件后5分钟定期测定的平均血液酒精浓度（BAC）为59 ± 1. 10、61 .+-. 7和62 .+-。7mg %。当在条件C之后恢复无限制访问时，每日酒精消费量恢复到与初始条件A下相似的水平（7.2 .+-. 0.5 g/kg）。当在条件C下乙醇浓度从5%增加到20%（v/v）时，在5%浓度下每次发作消耗的乙醇量显著低于在10%、15%和20%浓度下，并且在20%浓度下消耗的体积显著低于在5%、10%和15%浓度下。 然而，在停止饮酒后5分钟测量的平均BAC在四种浓度之间没有差异（范围：50 ± 0.5）。7到62 .+-. 7mg %）。结果表明，BAC是一个主要的因素，限制乙醇摄入的P大鼠。安排乙醇的可用性，每天一集，四天增加酒精摄入量时，计算每次饮酒事件，而不是每天。调度也没有增加摄入量在随后的不受限制的访问P大鼠。
The effects of scheduling the availability of ethanol on its voluntary consumption by the selectivity bred alcohol-preferring P rats were examined under three conditions: unrestricted 24 hr/day access (Condition A), access limited to a continuous 4 hr/day (Condition B), and access limited to 1 hr every 3 hr, 4 times/day (Condition C). Food and water were always available. Daily alcohol intakes (mean .+-. SEM) with Conditions A, B and C were 6.9 .+-. 0.2, 2.1 .+-. 0.2 and 4.4 .+-. 0.2 g/kg, respectively, while the intake per hour of availability increased from 0.3 .+-. 0.03 under Condition A to 1.1 .+-. 0.4 g/kg under Condition C. The amount of ethanol consumed per drinking episode under Conditions A, B and C were 1.1 .+-. 0.1, 2.1 .+-. 0.2 and 1.1 .+-. 0.03 g/kg, respectively. Mean blood alcohol concentrations (BACs), determined periodically during the dark cycle of Condition A and five minutes after drinking episodes under Conditions B and C, were 59 .+-. 10, 61 .+-. 7 and 62 .+-. 7 mg%, respectively. When unlimited access was reinstated after Condition C, daily alcohol consumption returned to a level similar to that under the initial Condition A (7.2 .+-. 0.5 g/kg). When the ethanol concentration was increased from 5 to 20% (v/v) under Condition C, the amount of ethanol consumed per episode at 5% was significantly less than at the 10, 15 and 20% concentrations, and the volume consumed was significantly lower at the 20% concentration than at the 5, 10 and 15% concentrations. However, mean BAC measured five minutes after cessation of drinking did not differ across the four concentrations (range: 50 .+-. 7 to 62 .+-. 7 mg%). The findings indicate that BAC is a major factor that limits ethanol intake in P rats. Scheduling the availability of ethanol to one episode per day for four days enhances alcohol intake when calculated per drinking episode but not per day. Scheduling also does not increase intake during subsequent unrestricted access in the P rats.