Neuroanatomical correlates of a lactate-induced anxiety attack.
Neuroanatomical correlates of a lactate-induced anxiety attack.
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DOI：
10.1001/archpsyc.1989.01810060013003
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发表时间：
1989-06
影响因子：
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通讯作者：
E. Reiman;M. Raichle;E. Robins;M. Mintun;Maureen J. Fusselman;P. T. Fox;J. Price;Kathryn A. Hackman
中科院分区：
文献类型：
--
作者：
E. Reiman;M. Raichle;E. Robins;M. Mintun;Maureen J. Fusselman;P. T. Fox;J. Price;Kathryn A. Hackman
使用局部血流的正电子发射断层扫描测量来评估惊恐障碍患者和正常对照受试者在乳酸钠输注之前和期间的局部神经元活动。采用一种分析正电子发射断层扫描数据的新技术来识别恐慌患者、非恐慌患者和对照组中与乳酸输注相关的局部血流的显着变化。乳酸引起的恐慌与颞极双侧血流量显着增加有关。双侧岛叶皮质、屏状核或外侧壳核；双侧上丘内或附近；以及左前小脑蚓部内或附近。在非惊慌患者或对照受试者中，乳酸输注与局部血流的显着变化无关。因此，所识别的区域似乎与焦虑发作有关。
Positron emission tomographic measurements of regional blood flow were used to assess local neuronal activity in patients with panic disorder and in normal control subjects before and during the infusion of sodium lactate. A new technique for the analysis of positron emission tomographic data was employed to identify significant changes in regional blood flow associated with lactate infusion in the panicking patients, nonpanicking patients, and controls. Lactate-induced panic was associated with significant blood flow increases bilaterally in the temporal poles; bilaterally in insular cortex, claustrum, or lateral putamen; bilaterally in or near the superior colliculus; and in or near the left anterior cerebellar vermis. Lactate infusion was not associated with significant changes in regional blood flow in the nonpanicking patients or control subjects. Thus, the identified regions seemed to be involved in an anxiety attack.