Oral health status of 207 head and neck cancer patients before, during and after radiotherapy
Oral health status of 207 head and neck cancer patients before, during and after radiotherapy
复制标题
DOI：
10.1007/s00784-007-0149-5
复制
发表时间：
2008-03-01
影响因子：
3.4
通讯作者：
Freire, Addah R.
中科院分区：
文献类型：
--
作者：
Jham, Bruno C.;Reis, Patricia M.;Freire, Addah R.
这项回顾性研究的目的是描述头颈部癌症（HNC）患者放疗（RT）前、放疗期间和放疗后的口腔健康状况。在RT之前，收集以下数据：存在不可恢复的牙齿、残根、未萌出的牙齿、使用假牙、牙周改变、龋齿、念珠菌病和口腔干燥症。RT期间对粘膜炎、念珠菌病和口干症进行评价。RT后继续随访患者，评价粘膜炎、念珠菌病、口干症、放射性龋齿和放射性骨坏死。对于统计分析，使用样本量、人群和百分比确定95%置信区间（0）。放疗前，120例（57.9%）患者出现口腔改变，即85例（41.0%）牙周病，44例（21.2%）残根，25例（12.0%）龋齿，15例（7.2%）念珠菌病，12例（5.8%）有未萌出牙。19名患者（9.1%）主诉口干。33例患者（15.9%）需要修复，而104例（50.2%）患者需要拔牙。放疗期间，粘膜炎80例（61.7%），念珠菌病60例（45.8%），口干82例（62.6%）。RT后，21例患者（19.2%）的粘膜炎持续存在，23例患者（21.1%）发现念珠菌病，58例患者（53.2%）报告口干。12例患者（11.0%）发生放射性龋，而6例患者（5.5%）发生放射性骨坏死。本文介绍的人口统计学特征将作为基线数据，以提供更多的流行病学信息，并确定未来的措施，预防和治疗RT引起的并发症和后遗症。
The aim of this retrospective study was to describe the oral health status of patients before, during, and after radiotherapy (RT) for the treatment of head and neck cancer (HNC). Before RT, the following data was collected: presence of unrecoverable teeth, residual roots, unerupted teeth, use of dentures, periodontal alterations, caries, candidiasis, and xerostomia. Mucositis, candidiasis, and xerostomia were evaluated during RT. Patients continued to be followed after RT for evaluation of mucositis, candidiasis, xerostomia, radiation caries, and osteoradionecrosis. For statistical analysis, 95% confidence intervals (0) were determined using sample size, population, and percentages. Before RT, 120 (57.9%) patients presented with alterations in the oral cavity namely, 85 (41.0%) with periodontal disease, 44 (21.2%) with residual roots, 25 (12.0%) with caries, 15 (7.2%) with candidiasis, and 12 (5.8%) had an unerupted tooth present. Xerostomia was a complaint of 19 patients (9.1%). Restorations were indicated for 3 3 patients (15.9%), whereas extraction was indicated for 104 (50.2%) patients. During RT, mucositis was found in 80 (61.7%) patients, candidiasis in 60 (45.8%), and xerostomia was a complaint of 82 patients (62.6%). After RT, mucositis persisted in 21 patients (19.2%), candidiasis was identified in 23 patients (21.1%), and xerostomia was reported by 58 patients (53.2%). Radiation caries developed in 12 patients (11.0%), whereas six patients (5.5%) developed osteoradionecrosis. The demographic profile herein presented will be useful as baseline data to provide additional epidemiological information and to determine future measures for prevention and treatment of RT-induced complications and sequelae.