On the chemical mechanism of gastric secretion.
On the chemical mechanism of gastric secretion.
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DOI：
10.1098/rspb.1905.0029
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发表时间：
1905-08-01
期刊：
影响因子：
--
通讯作者：
Edkins, JS
中科院分区：
文献类型：
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作者：
Edkins, JS
人们早就知道，某些物质进入胃后会刺激胃液的分泌。这被认为在某种意义上不依赖于单纯的粘膜机械刺激，而且一直认为胃腺的神经机制可能对某些局部化学刺激敏感。根据贝利斯和斯塔林一直认为的分泌胰液的机制的类比，很可能在消化的食物在胃内吸收的过程中，一种物质可能从粘膜细胞中分离出来，这些细胞进入血液或淋巴，随后刺激胃的分泌细胞进行功能活动。以下的观察结果支持这一观点：
It has long been known that the introduction of certain substances into the stomach provoke a secretion of gastric juice. This is regarded as in no sense depending upon mere mechanical stimulation of the mucous membrane, and it has been thought that the nervous mechanism of the gastric glands may be susceptible to certain local chemical stimuli. On the analogy of what has been held to be the mechanism at work in the secretion of pancreatic juice by Bayliss and Starling, it is probable that, in the process of absorption of digested food in the stomach, a substance may be separated from the cells of the mucous membrane which, passing into the blood or lymph, later stimulates the secretory cells of the stomach to functional activity. The following observations support this view:—