Local signals with global impacts and clinical implications: Lessons from the plasma membrane calcium pump (PMCA4)
Local signals with global impacts and clinical implications: Lessons from the plasma membrane calcium pump (PMCA4)
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DOI：
10.1016/j.bbamcr.2010.12.007
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发表时间：
2011-05-01
影响因子：
5.1
通讯作者：
Neyses, Ludwig
中科院分区：
文献类型：
--
作者：
Oceandy, Delvac;Mohamed, Tamer M. A.;Neyses, Ludwig
钙已被明确认为是几乎所有细胞类型中的关键信号信使。钙调节许多重要的细胞功能，包括细胞生长、肌丝收缩、细胞存活和凋亡以及基因转录。需要一种复杂的细胞钙调节机制来微调每个亚细胞位置的精确钙浓度，并将钙池携带的信号传递到正确的最终目标。在这篇文章中，我们将审查最近出现的质膜钙/钙调素依赖性ATP酶亚型4（PMCA 4）在调节钙信号的作用。然后，我们将专注于这种分子在心肌细胞中的功能，其中PMCA 4与几个关键信号分子形成蛋白质-蛋白质相互作用。最近的证据表明，在体内的生理功能和可能的临床意义的PMCA 4信号复合物。这篇文章是题为：第11届欧洲钙研讨会特刊的一部分。(C)2010爱思唯尔有限公司版权所有。
Calcium has been unequivocally regarded as a key signal messenger in almost every cell type. Calcium regulates a number of important cellular functions including cell growth, myofilament contraction, cell survival and apoptosis as well as gene transcription. A complex regulatory mechanism of cellular calcium is needed to fine tune the precise calcium concentration in each subcellular location and also to transmit the signals carried by the calcium pool to the correct end target. In this article we will review the recently emerging role of the plasma membrane calcium/calmodulin dependent ATPase isoform 4 (PMCA4) in regulating calcium signalling. We will then focus on the function of this molecule in cardiomyocytes, in which PMCA4 forms protein-protein interactions with several key signalling molecules. Recent evidence has shown in vivo physiological functionalities and possible clinical implications of the PMCA4 signalling complex. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. (C) 2010 Elsevier B.V. All rights reserved.