A mycobacterial heat-shock protein-responsive gamma delta T cell clone also responds to the homologous human heat-shock protein: a possible link between infection and autoimmunity.
A mycobacterial heat-shock protein-responsive gamma delta T cell clone also responds to the homologous human heat-shock protein: a possible link between infection and autoimmunity.
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分枝杆菌热休克蛋白反应性 γδT 细胞克隆也对同源人类热休克蛋白做出反应：感染和自身免疫之间可能存在联系。
DOI：
10.1093/infdis/163.1.156
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Finberg,RW
中科院分区：
文献类型：
--
作者：
Haregewoin,A;Singh,B;Gupta,RS;Finberg,RW
蛋白质和真核细胞通过增加统称为热休克蛋白（HSP）的蛋白质家族的合成来响应各种应激条件。其中之一是在许多细菌中高度保守的65 kDa HSP，是分枝杆菌免疫反应的主要靶点。从健康供体中获得的γδ T细胞克隆不仅识别65 kDa的分枝杆菌HSP，而且还识别该HSP蛋白的重组人同源物。与识别分枝杆菌HSP的ocfJ T细胞克隆一样，该克隆需要抗原呈递细胞进行抗原诱导的增殖，并且也可以通过CD3或γδ T细胞受体的δ链通过受体交联直接活化。这些数据表明，细菌抗原诱导的γδ T细胞应答可能导致对自体蛋白应答的细胞扩增，因此可能导致自身免疫的发展。
Prokaryotic and eukaryotic cells respond to a variety of stress conditions by increasing the synthesis of a family of proteins collectively known as heat-shock proteins (HSP). One of these, a 65-kDa HSP that is highly conserved in many bacteria, is a major target of the immune response to mycobacteria. A γδ T cell clone from a healthy donor that recognizes not only the 65-kDa mycobacterial HSP but also the recombinant human homologue of this HSP protein was raised. Like ocfJ T cell clones, which recognize mycobacterial HSP, the clone requires antigen-presenting cells for antigen-induced proliferation and can also bedirectly activated via receptor cross-linking through CD3 or the δ chain of the γδ T cell receptor. These data suggest that the induction of a γδ T cell response by bacterial antigens could lead to the expansion of cells that respond to autologous proteins and, therefore, may result in the development of autoimmunity.