Platelet-derived growth factor signaling in mesenchymal cells
Platelet-derived growth factor signaling in mesenchymal cells
复制标题
DOI：
10.2741/4090
复制
发表时间：
2013-01-01
影响因子：
3.1
通讯作者：
Norman, Jill
中科院分区：
文献类型：
--
作者：
Donovan, Johanna;Abraham, David;Norman, Jill
血小板源性生长因子（PDGF）及其受体是许多间充质来源的细胞类型（包括成纤维细胞和血管平滑肌细胞（VSMC））的主要促有丝分裂原。它们在增强这些细胞中的迁移和增殖反应以及细胞外基质合成中的作用使它们成为关键生物功能和组织疾病（包括组织重塑、瘢痕形成和纤维化）的关键调节剂。PDGF的活性已经在分子和细胞水平以及体内模型系统中被广泛表征。这反过来又导致了越来越多的基于PDGF的治疗方法，旨在加速或对抗组织修复中的缺陷。本文综述了PDGF在间充质细胞关键功能中的作用。目前在这一领域的许多发展主要集中在理解细胞分化，迁移，增殖和新兴的基于PDGF的疗法的发展的进步，因此将是本次审查的主要重点。
Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs). Their role in enhancing migratory and proliferative responses and extracellular matrix synthesis in these cells, make them key regulators of critical biological functions and in tissue diseases including tissue remodeling, scarring and fibrosis. The activities of the PDGFs have been extensively characterized at the molecular and cellular level and in in vivo model systems. This, in turn, has lead to an increasing number of PDGF-based therapies designed to accelerate or combat defects in tissue repair. This review aims to summarize recent developments in the role of PDGF in key mesenchymal cell functions. Many of the current developments in this field have primarily focused on advancements in understanding cell differentiation, migration, proliferation and the development of emerging PDGF-based therapies and hence will be primary focus of this review.