Non-invasive classification of microcalcifications with phase-contrast X-ray mammography
Non-invasive classification of microcalcifications with phase-contrast X-ray mammography
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DOI：
10.1038/ncomms4797
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发表时间：
2014-05-01
影响因子：
16.6
通讯作者：
Stampanoni, Marco
中科院分区：
文献类型：
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作者：
Wang, Zhentian;Hauser, Nik;Stampanoni, Marco
微钙化可以指示早期乳腺癌的诊断。在这里，我们报告了一种非侵入性的诊断方法，可能会区分不同类型的微钙化，使用X射线相衬成像。我们的方法利用了微钙化的吸收和小角度散射信号的互补性，同时获得与常规X射线管上的X射线光栅干涉仪。我们证明，新的方法具有100%的灵敏度和特异性时，应用于幻影数据，我们提供的证据，显示其歧视权力时，应用于固定活检，非固定组织标本和新鲜的，全乳房样本的技术的可靠性。所提出的方法可能会进一步发展，以提高早期乳腺癌的诊断，并有可能提高诊断准确性和减少不舒服的乳房活检的数量，或在广泛的微钙化的情况下，选择活检部位干预前。
Microcalcifications can be indicative in the diagnosis of early breast cancer. Here we report a non-invasive diagnostic method that may potentially distinguish between different types of microcalcifications using X-ray phase-contrast imaging. Our approach exploits the complementary nature of the absorption and small-angle scattering signals of microcalcifications, obtained simultaneously with an X-ray grating interferometer on a conventional X-ray tube. We demonstrate that the new approach has 100% sensitivity and specificity when applied to phantom data, and we provide evidence of the solidity of the technique by showing its discrimination power when applied to fixed biopsies, to non-fixed tissue specimens and to fresh, whole-breast samples. The proposed method might be further developed to improve early breast cancer diagnosis and has the potential to increase the diagnostic accuracy and reduce the number of uncomfortable breast biopsies, or, in case of widespread microcalcifications, to select the biopsy site before intervention.