Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression
Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression
复制标题
海马亚区动态功能连接异常与抑郁症工作记忆损伤相关
DOI：
10.1017/s0033291721004906
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发表时间：
2021-12-06
影响因子：
6.9
通讯作者：
Wang, Ying
中科院分区：
文献类型：
--
作者：
Shunkai, Lai;Su, Ting;Wang, Ying
摘要背景研究表明，重度抑郁症（MDD）患者海马结构和功能均发生改变。然而，还没有研究分析的动态功能连接（dFC）的海马各亚区的抑郁症。我们的目的是揭示海马亚区域dFC变异的模式-包括双侧吻侧和尾侧区域及其与抑郁症认知障碍的相关性。方法选取42例有精神症状的MDD初治患者和55例人口统计学匹配的健康对照者。采用滑动窗口分析法评价海马各亚区种子的全脑dFC。我们评估了组间差异的dFC变异值的每个海马子区在整个大脑和认知性能的MATRICS共识认知组合（MCCB）。最后，进行关联分析，以探讨它们之间的关系。结果与健康对照组相比，抑郁症患者左喙侧海马和左小脑前叶的dFC变异性降低（体素p < 0.005，聚类p < 0.0125，GRF校正），工作记忆、言语学习、视觉学习和社会认知的认知评分降低（均p < 0.05）。相关分析显示，抑郁症患者工作记忆与左前额叶-小脑左前叶dFC变异值呈正相关（r = 0.338，p = 0.029）。结论抑郁症患者海马各亚区存在明显的动态功能通路，提示海马-小脑连接功能障碍可能是抑郁症工作记忆损害的神经基础。
Abstract Background Previous studies have demonstrated structural and functional changes of the hippocampus in patients with major depressive disorder (MDD). However, no studies have analyzed the dynamic functional connectivity (dFC) of hippocampal subregions in melancholic MDD. We aimed to reveal the patterns for dFC variability in hippocampus subregions – including the bilateral rostral and caudal areas and its associations with cognitive impairment in melancholic MDD. Methods Forty-two treatment-naive MDD patients with melancholic features and 55 demographically matched healthy controls were included. The sliding-window analysis was used to evaluate whole-brain dFC for each hippocampal subregions seed. We assessed between-group differences in the dFC variability values of each hippocampal subregion in the whole brain and cognitive performance on the MATRICS Consensus Cognitive Battery (MCCB). Finally, association analysis was conducted to investigate their relationships. Results Patients with melancholic MDD showed decreased dFC variability between the left rostral hippocampus and left anterior lobe of cerebellum compared with healthy controls (voxel p < 0.005, cluster p < 0.0125, GRF corrected), and poorer cognitive scores in working memory, verbal learning, visual learning, and social cognition (all p < 0.05). Association analysis showed that working memory was positively correlated with the dFC variability values of the left rostral hippocampus-left anterior lobe of the cerebellum (r = 0.338, p = 0.029) in melancholic MDD. Conclusions These findings confirmed the distinct dynamic functional pathway of hippocampal subregions in patients with melancholic MDD, and suggested that the dysfunction of hippocampus-cerebellum connectivity may be underlying the neural substrate of working memory impairment in melancholic MDD.