Pretargeting for imaging and therapy in oncological nuclear medicine.
Pretargeting for imaging and therapy in oncological nuclear medicine.
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DOI：
10.1186/s41181-017-0026-8
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发表时间：
2017
影响因子：
4.6
通讯作者：
Barbet J
中科院分区：
文献类型：
--
作者：
Bailly C;Bodet-Milin C;Rousseau C;Faivre-Chauvet A;Kraeber-Bodéré F;Barbet J
肿瘤预靶向已经在临床前模型和临床试验中以几种不同的方式实施和测试了30多年。尽管结果非常有希望，但预靶向尚未获得市场批准，即使它可以被认为是最终的治疗诊断，将PET成像与短寿命正电子发射器和放射性核素发射β或α粒子的治疗相结合。我们回顾了多年来提出的预靶向方法，讨论了它们对成像（特别是PET成像）和治疗的适用性以及它们的局限性。审查pretargeting模式是亲和素-生物素系统，双特异性抗肿瘤X抗半抗原抗体和二价半抗原，抗体-寡核苷酸缀合物和放射性标记的互补寡核苷酸，和使用点击化学的方法。最后，我们讨论了最近的发展，如使用小的结合蛋白的预靶向，可能提供新的观点，癌症预靶向。虽然预靶向已经显示出前景，并证明了临床前和临床的原则证明，但需要全面的临床开发计划将预靶向转化为临床现实，理想地适应当前的治疗诊断和精准医学前景。
Oncological pretargeting has been implemented and tested in several different ways in preclinical models and clinical trials over more than 30 years. Despite highly promising results, pretargeting has not achieved market approval even though it could be considered the ultimate theranostic, combining PET imaging with short-lived positron emitters and therapy with radionuclides emitting beta or alpha particles. We have reviewed the pretargeting approaches proposed over the years, discussing their suitability for imaging, particularly PET imaging, and therapy, as well as their limitations. The reviewed pretargeting modalities are the avidin-biotin system, bispecific anti-tumour x anti-hapten antibodies and bivalent haptens, antibody-oligonucleotide conjugates and radiolabelled complementary oligonucleotides, and approaches using click chemistry. Finally, we discuss recent developments, such as the use of small binding proteins for pretargeting that may offer new perspectives to cancer pretargeting. While pretargeting has shown promise and demonstrated preclinical and clinical proof of principle, full-scale clinical development programs are needed to translate pretargeting into a clinical reality that could ideally fit into current theranostic and precision medicine perspectives.
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影响因子：
20.3
作者：
Forero, A;Weiden, PL;Meredith, RF
通讯作者：
Meredith, RF
影响因子：
9.3
作者：
Bodet-Milin, Caroline;Faivre-Chauvet, Alain;Kraeber-Bodere, Francoise
通讯作者：
Kraeber-Bodere, Francoise
影响因子：
4.7
作者：
JanevikIvanovska, E;Gautherot, E;GruazGuyon, A
通讯作者：
GruazGuyon, A
影响因子：
9.3
作者：
Altai, Mohamed;Perols, Anna;Tolmachev, Vladimir
通讯作者：
Tolmachev, Vladimir
影响因子：
3.3
作者：
Grillo-Lopez, Antonio J
通讯作者：
Grillo-Lopez, Antonio J