Design and sampling considerations, response rates, and representativeness in a Finnish Twin Family Study.
Design and sampling considerations, response rates, and representativeness in a Finnish Twin Family Study.
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芬兰双胞胎家庭研究的设计和抽样考虑因素、答复率和代表性。
DOI：
10.1017/s000156600000461x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Heikkilä,K
中科院分区：
文献类型：
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作者：
Kaprio,J;Rose,RJ;Sarna,S;Langinvainio,H;Koskenvuo,M;Rita,H;Heikkilä,K
由双胞胎父母、其配偶和子女组成的亲属关系为遗传流行病学研究提供了稳健而灵活的抽样设计。双胞胎家庭的设计规避了组合独立数据集时出现的一些抽样问题，并且这些设计提供了对母体影响、选型交配和 X 连锁的独特评估。不幸的是，对双胞胎父母家庭的实证研究受到相对较小的样本和在从志愿者双胞胎登记处确定家庭时固有的自我选择偏差的限制。从基于人群的双胞胎登记处抽取的大量具有代表性的同卵和异卵双胞胎父母队列，为双胞胎家庭研究提供了最佳抽样框架。本文回顾了基于芬兰双胞胎队列的初始家庭研究的抽样考虑因素，并评估了抽样双胞胎的代表性。通过邮寄调查问卷对 236 对双胞胎的配偶和成年子女（18 岁以上）进行了评估，这些双胞胎按性别和合子的比例大致相等。个人回答率超过86%，在472个核心家庭中，有464个（98.3%）最终由双胞胎家庭成员完成了问卷调查。抽样的双胞胎是根据生育力来选择的，以最大限度地提高所获得数据的统计能力，广泛代表了从队列中抽取的未选择的双胞胎，他们在年龄、性别和合子性上进行了匹配。这些结果表明芬兰队列在扩展双胞胎家庭研究设计方面具有巨大潜力。
Kinships composed of twin parents, their spouses and children, offer a robust and flexible sampling design for research in genetic epidemiology. Families-of-twins designs circumvent some of the sampling problems that arise when independent data sets are combined, and these designs provide unique evaluations of maternal influences, assortative mating and X-linkage. Unfortunately, empirical studies of families of twin parents have been limited by relatively small samples and by the self-selection biases intrinsic in ascertainment of families from volunteer twin registries.A large and representative cohort of monozygotic and dizygotic twin parents, drawn from a population-based twin registry, provides the optimal sampling frame for twin-family research. This paper reviews the sampling considerations underlying the initial family study based on the Finnish Twin Cohort and evaluates the representativeness of the sampled twins. Spouses and adult children (over 18 years) of 236 pairs of twins, about equally divided by gender and zygosity, were evaluated by a postal questionnaire. Individual response rates exceeded 86% and in 464 of the 472 nuclear families (98.3% ), at last one member of the twin's family completed the questionnaire. The sampled twins, selected for fecundity to maximize statistical power of the obtained data, were broadly representative of non-selected twins drawn from the Cohort, with whom they were matched on age, gender, and zygosity. Such results suggest that the Finnish Cohort has excellent potential for extended twin-family research designs.