Recent Advances in Conjugated Polymer Materials for Disease Diagnosis
Recent Advances in Conjugated Polymer Materials for Disease Diagnosis
复制标题
共轭高分子材料用于疾病诊断的最新进展
DOI：
10.1002/smll.201501700
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发表时间：
2016-02-10
期刊：
影响因子：
13.3
通讯作者：
Wang, Shu
中科院分区：
文献类型：
--
作者：
Lv, Fengting;Qiu, Tian;Wang, Shu
共轭聚合物非凡的光学放大和光捕获特性赋予了传感系统更高的灵敏度，这满足了早期癌症诊断的主要需求。基于荧光共振能量转移（FRET）的聚芴衍生物检测DNA甲基化和突变的最新进展，作为一种调节荧光反应的手段，证明了共轭聚合物作为疾病临床诊断的有力工具的巨大前景。为了促进不断变化的诊断需求，本综述强调了检测方法和FRET信号分析的发展。由于其卓越的亮度、优异的光稳定性和低毒性或无毒性，共轭聚合物被证实是体内成像的优越材料，并为未来的临床分子成像应用提供了可行性。共轭聚合物与临床研究的结合在疾病相关生物标志物的早期检测诊断、体内成像等方面显示出深远的影响，是一个兼具基础研究和应用问题视角的多学科科学领域。
The extraordinary optical amplification and light-harvesting properties of conjugated polymers impart sensing systems with higher sensitivity, which meets the primary demands of early cancer diagnosis. Recent advances in the detection of DNA methylation and mutation with polyfluorene derivatives based fluorescence resonance energy transfer (FRET) as a means to modulate fluorescent responses attest to the great promise of conjugated polymers as powerful tools for the clinical diagnosis of diseases. To facilitate the ever-changing needs of diagnosis, the development of detection approaches and FRET signal analysis are highlighted in this review. Due to their exceptional brightness, excellent photostability, and low or absent toxicity, conjugated polymers are verified as superior materials for in-vivo imaging, and provide feasibility for future clinical molecular-imaging applications. The integration of conjugated polymers with clinical research has shown profound effects on diagnosis for the early detection of disease-related biomarkers, as well as in-vivo imaging, which leads to a multidisciplinary scientific field with perspectives in both basic research and application issues.