Reduced risk of Alzheimer's disease with high folate intake: the Baltimore Longitudinal Study of Aging.
Reduced risk of Alzheimer's disease with high folate intake: the Baltimore Longitudinal Study of Aging.
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DOI：
10.1016/j.jalz.2005.06.001
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发表时间：
2005-07-01
期刊：
影响因子：
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通讯作者：
Brookmeyer, Ron
中科院分区：
文献类型：
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作者：
Corrada, Maria M;Kawas, Claudia H;Brookmeyer, Ron
背景技术背景：研究结果表明，阿尔茨海默病（AD）风险与几种维生素之间存在关联，并推测它们可用作预防剂。在这里，我们研究是否总摄入量（从饮食加补充剂摄入）的抗氧化维生素（E，C，类胡萝卜素）和B族维生素（叶酸，B（6），和B（12））与AD的风险降低。方法：参与者是579名非痴呆老年志愿者从巴尔的摩纵向研究老化谁完成饮食日记，并记录了7天的补充剂摄入量。考克斯回归被用来估计AD的相对风险（RR）与总维生素摄入量分为高于或低于推荐的膳食津贴（RDA）的水平分类：平均随访9.3年后，AD在57名参与者。叶酸摄入量高（RR，0.41; 95%置信区间[CI]，0.22至0.76），维生素E（RR，0.56; 95% CI，0.30 - 1.06）和维生素B（6）（RR，0.41; 95%CI，0.20至0.84）与AD风险降低相关，调整年龄，性别，教育和热量摄入后。当这3种维生素一起分析时，只有叶酸的总摄入量等于或高于RDA（RR，0.45; 95%CI，0.21至0.97）与AD风险显著降低相关。未发现维生素C、类胡萝卜素或维生素B（12）的总摄入量与AD风险之间存在关联。结论：这些发现表明，叶酸的总摄入量达到或超过RDA与AD风险降低相关。需要进一步研究叶酸或其他不可测量的因素是否可能导致这种风险降低。
BACKGROUND: Study findings have suggested an association between Alzheimer's disease (AD) risk and several vitamins and have speculated about their use as preventive agents. Here, we examine whether total intake (intake from diet plus supplements) of antioxidant vitamins (E, C, carotenoids) and B vitamins (folate, B(6), and B(12)) is associated with a reduced risk of AD.METHODS: Participants were 579 nondemented elderly volunteers from the Baltimore Longitudinal Study of Aging who completed dietary diaries and recorded supplement intake for a 7-day period. Cox regression was used to estimate the relative risk (RR) of AD associated with total vitamin intake categorized into levels above or below the Recommended Dietary Allowance (RDA).RESULTS: After a mean follow-up of 9.3 years, AD developed in 57 participants. Higher intake of folate (RR, 0.41; 95% confidence interval [CI], 0.22 to 0.76), vitamin E (RR, 0.56; 95% CI, 0.30 to 1.06), and vitamin B(6) (RR, 0.41; 95% CI, 0.20 to 0.84) were associated individually with a decreased risk of AD after adjusting for age, gender, education, and caloric intake. When these 3 vitamins were analyzed together, only total intake of folate at or above the RDA (RR, 0.45; 95% CI, 0.21 to 0.97) was associated with a significant decreased risk of AD. No association was found between total intake of vitamins C, carotenoids, or vitamin B(12) and risk of AD.CONCLUSIONS: These findings suggest that total intake of folate at or above the RDA is associated with a reduced risk of AD. Additional studies are necessary to further investigate whether folate or other(s) unmeasured factor(s) may be responsible for this reduction in risk.