What are our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research.
What are our AIMs? Interdisciplinary Perspectives on the Use of Ancestry Estimation in Disease Research.
复制标题
我们的目标是什么？
DOI：
10.1080/21507716.2012.717339
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Fullerton,StephanieM
中科院分区：
文献类型：
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作者：
Yu,Joon-Ho;Taylor,JanelleS;Edwards,KarenL;Fullerton,StephanieM
BackgroundAncestry estimation serves as a tool to identify genetic contributions to disease but may contribute to racial discrimination and stigmatization. We sought to understand user perspectives on the benefits and harms of ancestry estimation to inform research practice and contribute to debates about the use of race and ancestry in genetics.MethodsKey informant interviews with 22 scientists were conducted to examine scientists’ understandings of the benefits and harms of ancestry estimation.ResultsThree main perspectives were observed among key informant scientists who use ancestry estimation in genetic epidemiology research. Population geneticists self-identified as educators who controlled the meaning and application of ancestry estimation in research. Clinician-researchers were optimistic about the application of ancestry estimation to individualized risk assessment and personalized medicine. Epidemiologists remained ambivalent toward ancestry estimation and suggested a continued role for race in their research.ConclusionsWe observed an imbalance of control over the meaning and application of ancestry estimation among disciplines that may result in unwarranted or premature translation of ancestry estimation into medicine and public health. Differences in disciplinary perspectives need to be addressed if translational benefits of genetic ancestry estimation are to be realized.
