Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: potential agents for imaging the dopamine receptor.
Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: potential agents for imaging the dopamine receptor.
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18F-螺哌啶醇和 18F-氟哌啶醇动物模型比较：用于多巴胺受体成像的潜在药物。
DOI：
10.1016/0024-3205(83)90725-7
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Raichle,ME
中科院分区：
文献类型：
--
作者：
Welch,MJ;Kilbourn,MR;Mathias,CJ;Mintun,MA;Raichle,ME
使用相应的非标记化合物或硝基类似物通过交换反应制备了氟-18标记的氟哌啶醇和螺哌利多。在大鼠体内的研究表明，标记螺哌利多的分布具有较高的纹状体与小脑的比例，这是氟哌啶醇所没有的。18F-螺哌利多给药2小时后，血药浓度比为10.66±1.6。用~(18)F-螺哌利多给狒狒注射后，在给药2小时后，可清楚地看到多巴胺受体的富集区。
Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 ± 1.6 is obtained two hours after administration of the18F-spiroperidol. When18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.