THE MORTALITY AND PATHOLOGY OF HIV-INFECTION IN A WEST-AFRICAN CITY
THE MORTALITY AND PATHOLOGY OF HIV-INFECTION IN A WEST-AFRICAN CITY
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DOI：
10.1097/00002030-199312000-00005
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发表时间：
1993-12-01
期刊：
影响因子：
3.8
通讯作者：
DECOCK, KM
中科院分区：
文献类型：
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作者：
LUCAS, SB;HOUNNOU, A;DECOCK, KM
背景资料：艾滋病毒疾病在非洲流行，但相关的死亡率，潜在的病理学和CD 4 + T淋巴细胞计数以前没有在一项代表性的研究中进行过评估。这些数据有助于确定对艾滋病毒抗体阳性者的管理。HIV-1和HIV-2感染在Cote d 'Ivoire都很流行，HIV-2感染在非洲的病理学尚不清楚。方法：1991年对Cote d' Ivoire一家大型城市医院的连续成人医疗入院进行了研究，并对HIV阳性死亡病例进行了尸检。其中38%死亡，中位生存期为1周。在尸检中（n=294，包括24%的医院HIV阳性死亡），结核病（TB），菌血症（主要是革兰氏阴性杆菌）和脑弓形虫病造成53%的死亡。结核病见于54%的艾滋病定义病理学的尸体，肺孢子虫肺炎见于4%的尸体。死亡者的中位CD 4 + T淋巴细胞计数为
Background: HIV disease is epidemic in Africa, but associated mortality, underlying pathology and CD4+ T-lymphocyte counts have not previously been evaluated in a representative study. Such data help to determine the management of HIV-positive people. Both HIV-1 and HIV-2 infections are prevalent in Cote d'Ivoire, and the pathology of HIV-2 infection in Africa is unclear.Methods: Consecutive adult medical admissions to a large city hospital in Cote d'Ivoire were studied in 1991, and a sample of HIV-positive deaths autopsied.Results: Of 5401 patients evaluated, 50% were HIV-positive; 38% of these died, with a median survival of 1 week. At autopsy (n=294, including 24% of HIV-positive deaths in hospital), tuberculosis (TB), bacteraemia (predominantly Gram-negative rods) and cerebral toxoplasmosis caused 53% of deaths. TB was seen in 54% of cadavers with AIDS-defining pathology and Pneumocystis pneumonia in 4%. The median CD4+ T-lymphocyte counts in those who died was