Aqueous-based immobilization of initiator and surface-initiated ATRP to construct hemocompatible surface of poly (styrene-b-(ethylene-co-butylene)-b-styrene) elastomer.
Aqueous-based immobilization of initiator and surface-initiated ATRP to construct hemocompatible surface of poly (styrene-b-(ethylene-co-butylene)-b-styrene) elastomer.
复制标题
DOI：
10.1016/j.colsurfb.2013.06.029
复制
发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Jianwen Hou;Q. Shi;P. Stagnaro;W. Ye;Jing Jin;L. Conzatti;Jinghua Yin
中科院分区：
文献类型：
--
作者：
Jianwen Hou;Q. Shi;P. Stagnaro;W. Ye;Jing Jin;L. Conzatti;Jinghua Yin
表面引发原子转移自由基聚合（SI-ATRP）是一种控制良好的表面功能化的通用工具。然而，苯乙烯热塑性弹性体（STPEs）的表面改性面临着很大的挑战，因为典型的ATRP引发剂需要在有机溶剂中固定在STPEs上，而有机溶剂会溶解和破坏STPEs薄膜。在这项工作中，开发了一种简单的水基路线，将ATRP引发剂Br固定在STPEs模型共聚物苯乙烯-b-（乙烯-共丁烯）-b-苯乙烯弹性体（SEBS）表面。通过这种方法，成功地从SEBS表面制备了乙二醇甲基丙烯酸甲醚（OEGMA）功能聚合物刷。动力学研究表明，接枝密度与反应时间呈近似线性关系，表明链的生长符合“受控”过程。在SEBS-Br表面直接连接苯环的单键dbr键被证明是SI-ATRP的有效起始位点。良好定义的P（OEGMA）刷均匀覆盖表面，使SEBS薄膜具有优异的蛋白质吸附和血小板粘附性以及低溶血率。这项工作不仅操纵了SEBS表面，大大提高了其生物相容性，而且为促进苯乙烯基嵌段共聚物（sbc）表面的SI-ATRP铺平了道路。
Surface-initiated atom transfer radical polymerization (SI-ATRP) is a versatile tool for surface functionalization in a well-controlled manner. However, surface modification of styrenic thermoplastic elastomers (STPEs) faces a great challenge because immobilization of typical ATRP initiators onto STPEs needs to be carried out in organic solvent, which dissolves and destroys the STPEs film. In this work, a simple aqueous-based route is developed to immobilize ATRP initiators, Br, onto the surface of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS), chosen as a model copolymer of STPEs. In such a way, functional polymer brushes of ethylene glycol methyl ether methacrylate (OEGMA) are successfully prepared from the surface of SEBS. Kinetic investigations show an approximately linear relationship between grafting density and reaction time, indicating the growth of chains is coincident with a “controlled” process. Csingle bondBr bonds directly connected to benzene rings on the SEBS-Br surfaces are demonstrated to be effective initiation sites for SI-ATRP. The even coverage of the surface by well-defined P(OEGMA) brushes enable SEBS films to exhibit excellent resistance to protein adsorption and platelet adhesion as well as low hemolysis ratio. This work not only manipulates the SEBS surface to substantially improve its biocompatibility, but paves a way to facilitate SI-ATRP on the surface of styrene-based block copolymers (SBCs).