Understanding particle margination in blood flow - A step toward optimized drug delivery systems
Understanding particle margination in blood flow - A step toward optimized drug delivery systems
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DOI：
10.1016/j.medengphy.2015.08.009
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Gompper, Gerhard
中科院分区：
文献类型：
--
作者：
Mueller, Kathrin;Fedosov, Dmitry A.;Gompper, Gerhard
靶向递送药物和显像剂非常有希望为癌症等各种疾病的治疗开发新的策略。为了有效的靶向粘连，颗粒必须在血液流动中向壁上迁移-这一过程被称为边际化。由于可用载体的种类繁多，因此需要很好地了解它们在血流中的边际特性取决于不同的流动条件和颗粒特性。我们使用基于粒子的介观流体动力学模拟方法来研究不同载体对大范围血细胞(红细胞体积分数)和流速的边际作用。我们的结果表明，与载体大小相比，边际化强烈依赖于靠近壁面的可用自由空间的厚度，即所谓的红细胞无细胞层(RBC-FL)。几微米大小的载体与RBC-FL厚度相当，边际比亚微米对应的载体更好。通常，可变形载体比刚性颗粒表现出更差的边缘特性。颗粒边际化也被发现在具有与毛细血管相当的特征大小的小通道中最为明显。最后，讨论了不同的边际作用机制。(C)2015年IPEM。爱思唯尔有限公司出版。保留所有权利。
Targeted delivery of drugs and imaging agents is very promising to develop new strategies for the treatment of various diseases such as cancer. For an efficient targeted adhesion, the particles have to migrate toward the walls in blood flow - a process referred to as margination. Due to a huge diversity of available carriers, a good understanding of their margination properties in blood flow depending on various flow conditions and particle properties is required. We employ a particle-based mesoscopic hydrodynamic simulation approach to investigate the margination of different carriers for a wide range of hematocrits (volume fraction of red blood cells) and flow rates. Our results show that margination strongly depends on the thickness of the available free space close to the wall, the so-called red blood cell-free layer (RBC-FL), in comparison to the carrier size. The carriers with a few micrometers in size are comparable with the RBC-FL thickness and marginate better than their sub-micrometer counterparts. Deformable carriers, in general, show worse margination properties than rigid particles. Particle margination is also found to be most pronounced in small channels with a characteristic size comparable to blood capillaries. Finally, different margination mechanisms are discussed. (C) 2015 IPEM. Published by Elsevier Ltd. All rights reserved.